目的：研究栀子提取物类脂质体在大鼠体内的药物分布特点及靶向性。方法：采用改良薄膜分散法制备栀子提取物类脂

质体。将30 只大鼠按体质量随机均分为空白组、栀子提取物（57 mg/kg）组和栀子提取物类脂质体（131 mg/kg）组，ig 相应药物，空

白组ig 等体积蒸馏水，每天1 次，连续7 d。末次给药1 h 后，取大鼠心、肝、脾、肺、肾组织，采用高效液相色谱法检测其中栀子提取

物有效成分栀子苷的含量，通过药物靶向指数（DTI）定量评价栀子提取物类脂质体的体内靶向性。结果：与栀子提取物组比较，

栀子提取物类脂质体组大鼠心、脾、脑组织中栀子苷含量明显增加（P＜0.01），DTI分别为1.718、1.972、13.071；肝、肾组织中栀子苷

含量明显降低（P＜0.01），DTI分别为0.431、0.467。结论：栀子提取物类脂质体改变了栀子苷在大鼠体内的组织分布，可靶向作用

于脑组织，减少了肝的首关效应。

OBJECTIVE：To study distribution and targeting of Gardenia jasminoides extract niosomes in rats. METHODS：G.

jasminoides extract niosomes were prepared by modified thin film dispersion method. 30 rats were randomly divided into G. jasminoides

extract group（57 mg/kg）and G. jasminoides extract liposome group（131 mg/kg）according to their weight. They were given

relevant medicine intragastrically，once a day，for consecutive 7 days. 1 h after last administration，heart，liver，spleen，lung and

kidney tissue were isolated，and HPLC method was adopted to the contents of active ingredients gardenoside in them. The targeting

of G. jasminoides extract niosomes was evaluated by DTI quantitatively. RESULTS：Compared with G. jasminoides extract group，

the contents of gardenoside in heart，spleen and brain tissue of rats increased significantly in G. jasminoides extract niosomes group

（P＜0.01），and DTI were 1.718，1.972 and 13.071；the contents of gardenoside in liver and kidney decreased significantly（P＜

0.01），and DTI were 0.431 and 0.467，respectively. CONCLUSIONS：G. jasminoides extract niosomes change the distribution of

gardenoside in rats，showing brain targeting effect and decreasing first pass effect for liver.