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富血小板血浆宫内输注联合固肾安胎丸治疗复发性流产的临床观察
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| 篇名： | 富血小板血浆宫内输注联合固肾安胎丸治疗复发性流产的临床观察 |
| TITLE： | Clinical observation of platelet-rich plasma intrauterine infusion combined with Gushen antai pills in the treatment of recurrent abortion |
| 摘要： | 目的 探究富血小板血浆（PRP）宫内输注联合固肾安胎丸治疗复发性流产（RSA）的疗效及对患者子宫内膜容受性、激素水平的影响。方法选择2021年1月至2024年1月于我院治疗的108例RSA患者，按随机数字表法分为对照组和研究组，每组54例。在常规治疗的基础上，对照组患者采用固肾安胎丸治疗，研究组患者采用PRP宫内输注联合固肾安胎丸治疗。比较两组患者的临床疗效，治疗前后的中医证候积分、子宫内膜容受性[子宫内膜厚度（EST）、螺旋动脉阻力指数（RI）、搏动指数（PI）]、激素[孕酮（P）、雌二醇（E2）、人绒毛膜促性腺激素（HCG）]水平，以及妊娠结局；记录两组患者的不良反应发生情况。结果研究组患者的总有效率（91.44%vs.81.48%）、婴儿活产率（96.30%vs.83.33%）均显著高于对照组（P＜0.05）。治疗后，两组患者的各项中医证候积分及总积分、螺旋动脉RI、PI水平均显著低于同组治疗前，且研究组显著低于对照组（P＜0.05）；P、E2、HCG、EST水平均显著高于同组治疗前，且研究组显著高于对照组（P＜0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论PRP宫内输注联合固肾安胎丸治疗RSA的疗效显著，能够改善患者的中医证候，提高子宫内膜容受性，调节激素水平，改善妊娠结局，且安全性较好。 |
| ABSTRACT： | OBJECTIVE To explore the efficacy of platelet-rich plasma （PRP） intrauterine infusion combined with Gushen antai pills in the treatment of recurrent abortion （RSA） and its impacts on endometrial receptivity and hormone levels in patients. METHODS A total of 108 patients with RSA treated in our hospital from January 2021 to January 2024 were selected and evenly divided into control group and study group using the random number table method， with 54 cases in each group. On the basis of conventional treatment， patients in the control group were administered with Gushen antai pills， while patients in the study group received PRP intrauterine infusion combined with Gushen antai pills. The clinical efficacy， TCM syndrome scores before and after treatment， endometrial receptivity [endometrial thickness （EST）， spiral artery resistance index （RI）， and pulsatility index （PI）]， hormone [progesterone （P）， estradiol （E2）， and human chorionic gonadotropin （HCG）] levels， as well as pregnancy outcomes， were compared between the two groups. Additionally， the occurrence of adverse reactions in both groups was recorded. RESULTS The total effective rate （91.44% vs. 81.48%） and infant live birth rate （96.30% vs. 83.33%） of the study group were significantly higher than those of the control group （P＜0.05）. Following treatment， various TCM syndrome scores and total score， spiral artery RI and PI levels in both groups were markedly lower than those in the same groups before treatment， with the study group showing significantly lower levels than the control group（P＜0.05）. Conversely， the P， E2， HCG and EST levels in both groups were significantly higher than those in the same groups before treatment， and the study group exhibited notably higher levels than the control group （P＜0.05）. There was no statistically significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）. CONCLUSIONS PRP intrauterine infusion combined with Gushen antai pills has good clinical efficacy in the treatment of RSA. It can improve TCM syndromes， enhance endometrial receptivity， regulate hormone levels and improve pregnancy outcomes， and it is highly safe. |
| 期刊： | 2025年第36卷第24期 |
| 作者： | 张赛男；李俊峰；辛淑文；白爱红；李荣香；付秀虹 |
| AUTHORS： | ZHANG Sainan，LI Junfeng，XIN Shuwen，BAI Aihong，LI Rongxiang，FU Xiuhong |
| 关键字： | 富血小板血浆；固肾安胎丸；复发性流产；子宫内膜容受性；激素；疗效 |
| KEYWORDS： | platelet-rich plasma； Gushen antai pills； recurrent abortion； endometrial receptivity； hormone； efficacy |
| 阅读数： | 2 次 |
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