返回 
加入收藏
比阿培南对重症感染患者丙戊酸钠血药浓度影响的回顾性研究
x
请在关注微信后，向客服人员索取文件
| 篇名： | 比阿培南对重症感染患者丙戊酸钠血药浓度影响的回顾性研究 |
| TITLE： | Effects of biapenem on the blood concentration of sodium valproate in patients with severe infections：a re-trospective study |
| 摘要： | 目的 分析比阿培南对重症感染患者丙戊酸钠（VPA）血药浓度的影响。方法回顾性收集2021年1月－2024年5月我院收治的使用比阿培南治疗重症感染的同时或先后使用了VPA预防或治疗癫痫的患者资料。分析联用比阿培南、用药顺序、联用天数、比阿培南剂量及停用时间对VPA血药浓度的影响。结果共纳入70例患者的117个VPA血药浓度结果。单用VPA时，先用比阿培南与后用比阿培南患者的VPA稳态血药浓度比较无显著差异（P＞0.05）。比阿培南联用1～3d者与未联用者的VPA稳态血药浓度比较无显著差异（P＞0.05）；但未联用比阿培南者的VPA稳态血药浓度显著高于联合用药4～7d者和＞7d者（P＜0.001）。随着联用时间的延长，VPA血药浓度逐渐降低（P＜0.001），但联合用药＞7d者与联合用药4～7d者比较无显著差异（P＞0.05）。联合用药1～3d后比阿培南不同停用时间者之间的VPA血药浓度比较均无显著差异（P＞0.05）；但联合用药＞3d者的VPA血药浓度较未联用者、联合用药＞3d停用比阿培南4～7d或停用＞7d者均显著降低（P＜0.001）。比阿培南日剂量＞1.0g者与日剂量＜1.0g者的VPA血药浓度比较无显著差异（P＞0.05）。结论联用比阿培南1～3d对VPA血药浓度的影响较小，联合用药＞3d的患者的VPA血药浓度可在停用比阿培南4～7d后恢复。 |
| ABSTRACT： | OBJECTIVE To analyze the effects of biapenem on the blood concentration of sodium valproate （VPA） in patients with severe infections. METHODS A retrospective collection of patient data was conducted， encompassing individuals admitted to our hospital from January 2021 to May 2024 who were treated with biapenem for severe infections and concurrently or sequentially administered VPA for the prevention or treatment of epilepsy. The effects of various factors on the blood concentration of VPA， including the combination of biapenem， the sequence of biapenem administration， the number of days of biapenem combination， the dosage of biapenem， and the time after biapenem discontinuation. RESULTS A total of 70 patients with 117 VPA blood concentration results were included in this study. When VPA was used alone， no statistically significant difference was observed in the steady-state blood concentrations of VPA between patients who received biapenem first and those who received it later （P＞ 0.05）. There was no statistically significant difference between the steady-state concentration of VPA in patients who received biapenem in combination for 1 to 3 days and those who did not receive the combination therapy （P＞0.05）. The steady-state concentration of VPA in patients not receiving biapenem combination therapy was significantly higher than that of the patients who received combination therapy for 4 to 7 days and more than 7 days （P＜0.001）. With the prolonged duration of combination therapy， the blood concentration of VPA gradually decreased （P＜0.001）. However， no statistically significant difference was observed between the group receiving combination therapy for more than 7 days and the group receiving it for 4 to 7 days （P＞ 0.05）. After 1 to 3 days of combination therapy， no statistically significant differences in VPA blood concentrations were observed among patients with different discontinuation times of biapenem （P＞0.05）. The blood concentration of VPA in patients who received combination therapy for more than 3 days was significantly lower than those who discontinued biapenem 4 to 7 days or more than 7 days after more than 3 days of combination therapy（P＜0.001）. There was no statistically significant difference in VPA blood concentrations between patients receiving a daily biapenem dose ＞1.0 g and those receiving a daily dose ＜1.0 g （P＞0.05）. CONCLUSIONS The concomitant administration of biapenem for 1-3 days has a minimal impact on the blood concentration of VPA. In patients receiving combination therapy for longer than 3 days， VPA blood concentrations return to baseline levels chouxiaoh@163.com within 4-7 days after biapenem discontinuation. |
| 期刊： | 2025年第36卷第24期 |
| 作者： | 丑晓华；张倩；刘志东；姜道利 |
| AUTHORS： | CHOU Xiaohua，ZHANG Qian，LIU Zhidong，JIANG Daoli |
| 关键字： | 癫痫；重症感染；丙戊酸钠；比阿培南；联合应用；血药浓度 |
| KEYWORDS： | epilepsy； severe infection； sodium valproate； |
| 阅读数： | 0 次 |
| 本月下载数： | 0 次 |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！
