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基于德尔菲法构建结直肠癌治疗药物选择评价指标体系
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| 篇名： | 基于德尔菲法构建结直肠癌治疗药物选择评价指标体系 |
| TITLE： | Construction of evaluation index system for the selection of therapeutic drugs for colorectal carcinoma based on Delphi method |
| 摘要： | 目的 构建结直肠癌治疗药物选择评价指标体系，为临床用药决策提供依据。方法通过文献调查、专家调研，初步构建结直肠癌治疗药物选择评价指标体系框架；采用德尔菲法，向40名从事抗肿瘤药物使用和评价工作的专家进行函询，最终形成结直肠癌治疗药物选择评价体系。结果两轮函询的问卷回收率均为100%；专家权威系数分别为0.82和0.85，Kendall’sW协调系数分别为0.251和0.252（χ2检验的P值均小于0.05）。最终构建的评价体系包含6个一级指标（安全性、有效性、经济性、适宜性、创新性、可及性）和29个二级指标（疾病控制率、对目标疾病的精准治疗、客观缓解率、临床用药是否符合权威推荐等）；其中，有效性、可及性的重要性评分平均值（4.60、4.30分）排名靠前，“疾病控制率”“对目标疾病的精准治疗”的权重（均为0.0352）较高。结论本研究成功构建了符合临床实际的结直肠癌治疗药物选择评价指标体系。 |
| ABSTRACT： | OBJECTIVE To establish an evaluation index system for the selection of therapeutic drugs for colorectal carcinoma， providing a basis for clinical medication decision-making. METHODS A preliminary framework for the evaluation index system for the selection of therapeutic drugs for colorectal carcinoma was constructed through literature research and expert surveys. Using the Delphi method， consultations were conducted with 40 experts engaged in the use and evaluation of antitumor drugs， ultimately forming the evaluation system for selecting therapeutic drugs for colorectal carcinoma. RESULTS The effective recovery rate of questionnaires for both rounds of inquiries was 100%， with the reliability coefficients of 0.82 and 0.85. The Kendall’s W coordination coefficients were 0.251 and 0.252 （the P values of χ 2 tests were both less than 0.05）. The final evaluation system constructed included 6 first-level indicators （safety， efficacy， cost-effectiveness， suitability， innovation， and accessibility） and 29 second-level indicators （such as disease control rate， precise treatment of target diseases， objective remission rate， and whether clinical medication complies with authoritative recommendations）. Among these， efficacy and accessibility received high average importance scores （4.60， 4.30 points）， with “disease control rate” and “precision treatment for target disease” carrying relatively high weights （both were 0.035 2）. CONCLUSIONS This study successfully established a drug evaluation index system for the selection of therapeutic drugs for colorectal cancer that aligns with clinical practice. |
| 期刊： | 2025年第36卷第24期 |
| 作者： | 唐莲；朱龙驯；丰攀峰 |
| AUTHORS： | TANG Lian，ZHU Longxun，FENG Panfeng |
| 关键字： | 结直肠癌；药物选择；评价指标体系；德尔菲法 |
| KEYWORDS： | colorectal carcinoma； drug selection； evaluation index system； Delphi method |
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