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石菖蒲-远志药对改善认知障碍的药理机制研究进展
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| 篇名： | 石菖蒲-远志药对改善认知障碍的药理机制研究进展 |
| TITLE： | Research progress on the pharmacological mechanisms of Acorus tatarinowii-Polygala tenuifolia herb pair in ameliorating cognitive impairment |
| 摘要： | 认知障碍是全球老龄化社会面临的重大公共卫生挑战，目前缺乏有效治疗措施。中药药对以其配伍严谨、协同增效的特点，在临床应用中显示出独特优势。石菖蒲-远志是治疗认知障碍的经典药对，在多个中药复方（如开心散、生慧汤、远志散等）中广泛应用。本文综述了石菖蒲、远志及其配伍复方改善认知障碍的药理机制，发现其可通过减少β淀粉样蛋白沉积和抑制Tau蛋白过度磷酸化、抑制炎症反应、改善氧化应激、保护神经元和调节神经递质、调节血脑屏障结构和功能、调节自噬等作用机制，发挥改善认知障碍的作用。后续可深入分析石菖蒲-远志药对改善认知障碍的活性成分，增加相关临床试验验证，为中医药治疗认知障碍提供理论依据和研究思路。 |
| ABSTRACT： | Cognitive impairment is a major public health challenge facing global aging societies， and currently lacks effective treatment measures. Herb pair， characterized by their rigorous compatibility and synergistic effects， demonstrate unique advantages in clinical practice. Acorus tatarinowii-Polygala tenuifolia is a classic herbal pair for treating cognitive impairment， widely utilized in various traditional Chinese medicine formulations， such as Kaixin san， Shenghui tang， and Yuanzhi san. This article summarizes the pharmacological mechanisms of A. tatarinowii， P. tenuifolia and their compatible compound prescriptions in ameliorating cognitive impairment. It is found that they can exert effects in ameliorating cognitive impairment through mechanisms such as reducing amyloid β-protein deposition and inhibiting excessive phosphorylation of Tau protein， suppressing inflammatory responses， alleviating oxidative stress， protecting neurons and regulating neurotransmitters， modulating the structure and function of the blood- brain barrier， and regulating autophagy. Subsequently， in-depth analysis can be conducted on the active ingredients of A. tatarinowii- P. tenuifolia herb pair that ameliorate cognitive impairment， along with the addition of relevant clinical trials for verification. This will provide theoretical foundations and research approaches for the treatment of cognitive impairment using traditional Chinese medicine. |
| 期刊： | 2025年第36卷第23期 |
| 作者： | 杨鑫；许玉珉；闫化雨；刘源；刘诗雨；徐红彩；吴亚博 |
| AUTHORS： | YANG Xin，XU Yumin，YAN Huayu，LIU Yuan，LIU Shiyu，XU Hongcai，WU Yabo |
| 关键字： | 石菖蒲；远志；药对；认知障碍；阿尔茨海默病；血管性认知障碍；复方；活性成分 |
| KEYWORDS： | Acorus tatarinowii； Polygala tenuifolia； herb pair； cognitive impairment； Alzheimer’s disease； vascular cognitive |
| 阅读数： | 14 次 |
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