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支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展
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| 篇名： | 支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展 |
| TITLE： | Research progress on the pathogenesis of airway mucus hypersecretion in bronchial asthma and the intervention of traditional Chinese medicine |
| 摘要： | 支气管哮喘（简称“哮喘”）是呼吸系统常见的慢性气道炎症疾病之一，迁延难愈。气道黏液高分泌（AMH）是导致哮喘急性发作的重要因素。中药具有多途径、多靶点、多环节的治疗优势，其在干预哮喘AMH方面的作用机制逐渐受到关注。中药基于祛痰化饮等方法干预哮喘，可有效缓解患者症状。本文综述发现，哮喘AMH的发病机制与黏液纤毛清除功能下降和黏液分泌功能增强相关；单味中药（桔梗等）、中药有效成分（清半夏多糖等）及中药复方（清热化痰方药等）可通过调控磷脂酰肌醇3激酶/蛋白激酶B、Janus激酶/信号转导及转录激活蛋白等信号通路，抑制气道炎症反应和氧化应激以及恢复黏液层自身水盐比例来改善哮喘AMH。 |
| ABSTRACT： | Bronchial asthma （abbreviated as asthma） is one of the common chronic airway inflammatory diseases in the respiratory system， which is difficult to cure. Airway mucus hypersecretion （AMH） is an important factor leading to acute asthma attacks. Traditional Chinese medicine （TCM） possesses therapeutic advantages characterized by multiple pathways， multiple targets， and multiple links， and its mechanism of action in intervening in AMH has gradually drawn attention. TCM can effectively alleviate the symptoms of patients by intervening in asthma through methods such as eliminating phlegm and eliminating fluid retention. This review finds that the pathogenesis of asthma-associated AMH is correlated with decreased mucociliary clearance function and enhanced mucus secretion function； single TCM （such as Platycodon grandiflorum）， effective components of TCM （such as pinellia polysaccharides）， and compound prescriptions （mainly heat-clearing and phlegm-resolving prescriptions， etc.） can improve asthma-associated AMH by regulating the PI3K/Akt and JAK/STAT signaling pathways， inhibiting airway inflammatory responses， oxidative stress， and recovering the water-salt ratio of the mucus layer itself. |
| 期刊： | 2025年第36卷第22期 |
| 作者： | 陈瑞怡；春柳；李伟珂；杨菊；王至婉 |
| AUTHORS： | CHEN Ruiyi，CHUN Liu，LI Weike，YANG Ju，WANG Zhiwan |
| 关键字： | 支气管哮喘；气道黏液高分泌；中医药；发病机制 |
| KEYWORDS： | bronchial asthma； airway mucus hypersecretion； traditional Chinese medicine； pathogenesis； research progress |
| 阅读数： | 9 次 |
| 本月下载数： | 0 次 |
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