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开心颗粒的水提工艺优化
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| 篇名： | 开心颗粒的水提工艺优化 |
| TITLE： | Optimization of water extraction technology of Kaixin granules |
| 摘要： | 目的 优化开心颗粒的水提工艺。方法采用超高效液相色谱-串联质谱法测定指标成分人参皂苷Rg1、人参皂苷Re、人参皂苷Rb1、细叶远志皂苷、远志酮Ⅲ、3，6′-二芥子酰基蔗糖的含量；以提取次数、提取时间、加水量为考察因素，设计正交实验，以上述6个指标成分含量以及出膏率为评价指标，采用层次分析法-熵权法确定各指标的组合权重，结合灰色关联度分析、反向传播（BP）神经网络进行工艺优化并验证。结果正交实验与灰色关联度分析筛选的最优水提工艺为提取3次，首次加水10倍量，后两次加水8倍量，提取时间1h；验证实验的综合评分均值为91.10（RSD为0.31%，n＝3）。BP神经网络预测的最优水提工艺为提取3次，每次加水10倍量，提取时间1.5h；验证实验的综合评分均值为95.89（RSD为0.73%，n＝3）。结合实际生产，最终确定最优水提工艺为提取3次，首次加水10倍量，后两次加水8倍量，提取时间1h。结论所得开心颗粒的最优水提工艺稳定可行。 |
| ABSTRACT： | OBJECTIVE To optimize the water extraction technology for Kaixin granules. METHODS UPLC-MS/MS method was established for the simultaneous determination of ginsenoside Rg1， ginsenoside Re， ginsenoside Rb1， tenuifolin， polygalaxanthone Ⅲ and 3， 6′-disinapoyl-sucrose. An orthogonal test was designed with extraction times， extraction duration， and the volume of added water as factors. Using the contents of the aforementioned six indicator components and the extract yield as evaluation indexes， analytic hierarchy process-entropy weight method was employed to determine the combined weights of each indicator. Subsequently， process optimization and validation were conducted by integrating grey relational analysis （GRA） and back propagation （BP） neural network. RESULTS The water extraction technology optimized by the orthogonal test and GRA was 10- fold water for the first decoction and 8-fold water for the subsequent two， extracting 3 times，extracting for 1 h each time； the average comprehensive score of the validation experiment was 91.10 （RSD＝0.31%， n＝3）. The water extraction technology optimized by BP neural network was extracting 3 times with 10-fold water added each time， extracting for 1.5 h each time； the average comprehensive score of the validation experiment was 95.89 （RSD＝0.73%， n＝3）. Considering practical production requirements， the optimal water extraction technology was extraction performed three times， with 10-fold water for the first decoction and 8-fold water for the subsequent two extractions， with an extraction time of 1 h each. CONCLUSIONS The optimized water extraction technology for Kaixin granules is stable and feasible. |
| 期刊： | 2025年第36卷第22期 |
| 作者： | 吴作敏；白淑贤；宁萌；王韵旨；马慧芬；董敬远；杨忠杰；谢治深；张振强；于晓涛 |
| AUTHORS： | WU Zuomin，BAI Shuxian，NING Meng， WANG Yunzhi，MA Huifen，DONG Jingyuan，YANG Zhongjie，XIE Zhishen，ZHANG Zhenqiang，YU Xiaotao |
| 关键字： | 开心颗粒；水提工艺；层次分析法；熵权法；灰色关联度分析；正交实验；BP神经网络 |
| KEYWORDS： | Kaixin granules； water extraction technology； analytic hierarchy process； entropy weight method； grey relational |
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