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中药活性成分及复方通过NF-κB通路干预脓毒症相关性急性肾损伤的作用机制
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| 篇名： | 中药活性成分及复方通过NF-κB通路干预脓毒症相关性急性肾损伤的作用机制 |
| TITLE： | Mechanism of active ingredients and compound formula of traditional Chinese medicine intervening in sepsis-associated acute kidney injury via the NF-κB signaling pathway |
| 摘要： | 脓毒症相关性急性肾损伤（SA-AKI）是由脓毒症引起的急性肾损伤，起病急、病情重、死亡率高。核因子κB（NF-κB）信号通路的异常激活可导致肾脏炎症级联反应、氧化应激、细胞凋亡和焦亡、微循环障碍等病理进程，从而促进SA-AKI的病情发展。近年来中药在防治SA-AKI的基础研究中取得了显著进展，其中NF-κB作为关键因子发挥了重要作用。本文总结了近年来中药活性成分及复方基于NF-κB信号通路干预SA-AKI的研究成果，阐述了黄酮类、酚类、苷类、萜类、醌类和生物碱类等多种中药活性成分，以及芪黄解毒化瘀饮、黄芪救逆汤、血必净注射液等中药复方，通过调控NF-κB介导的Toll样受体4/髓系分化初级反应蛋白质88/NF-κB、去乙酰化酶1/NF-κB、NF-κB/NOD样受体热蛋白结构域相关蛋白3等多条信号通路，显著抑制肾脏炎症反应、氧化应激、细胞凋亡和焦亡、微循环障碍等，从而减轻SA-AKI，改善肾功能。 |
| ABSTRACT： | Sepsis-associated acute kidney injury （SA-AKI） is an acute kidney injury caused by sepsis， characterized by acute onset， severe progression and high mortality. The abnormal activation of the nuclear factor-κB （NF-κB） signaling pathway can lead to pathological processes such as renal inflammatory cascade reactions， oxidative stress， apoptosis and pyroptosis， and microcirculatory dysfunction， thereby promoting the development of SA-AKI. In recent years， the basic research on the prevention and treatment of SA-AKI with traditional Chinese medicine （TCM） has made significant progress， among which NF-κB plays an important role as a key factor. This article summarizes the research findings over the past few years on active ingredients and compound formula of TCM interventions for SA-AKI via the NF-κB signaling pathway. It elaborates on various active ingredients of TCM， such as flavonoids， phenols， glycosides， terpenoids， quinones and alkaloids， as well as TCM compound formulations including Qihuang jiedu huayu decoction， Huangqi jiuni decoction， and Xuebijing injection， etc. These interventions significantly inhibit renal inflammatory responses， oxidative stress， apoptosis， pyroptosis and microcirculatory dysfunction by regulating multiple NF-κB-mediated signaling pathways， such as Toll-like receptor 4/myeloid differentiation primary response protein 88/NF- κB， sirtuin 1/NF- κB， NF- κB/NOD-like receptor family pyrin domain-containing protein 3， thereby alleviating SA-AKI and improving renal function. |
| 期刊： | 2025年第36卷第21期 |
| 作者： | 向敏；陈思源 |
| AUTHORS： | XIANG Min，CHEN Siyuan |
| 关键字： | 脓毒症；急性肾损伤；核因子κB；中药；活性成分；复方 |
| KEYWORDS： | sepsis； acute kidney injury； nuclear factor-κB； traditional Chinese medicine； active ingredients； compound formula |
| 阅读数： | 11 次 |
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