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中药复方药效物质基础分析技术研究进展
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| 篇名： | 中药复方药效物质基础分析技术研究进展 |
| TITLE： | Research progress in analytical technologies for characterizing pharmacodynamic substance basis of traditional Chinese medicine compound prescriptions |
| 摘要： | 中药复方是中医药理论体系的重要实践载体，具有多成分、多靶点等复杂特点，其药效物质基础研究逐渐成为推动中药现代化发展的关键所在。近年来，中药复方药效物质基础研究的新思路和新理论不断被提出。本文通过对靶向垂钓技术、谱效关系分析、血清药物化学、网络药理学、高通量筛选技术、细胞膜色谱技术等分析技术进行归纳总结，发现其在靶标特异性分析、成分-药效关联分析、体内外物质基础辨识、多靶点机制预测、活性成分筛选及细胞膜受体互作分析等方面展现出独特优势，弥补了传统研究方法的不足，提升了中药复方药效物质基础研究的系统性与精准性，可为中药复方的推广及临床应用提供理论支持。 |
| ABSTRACT： | Traditional Chinese medicine （TCM） compound prescriptions serve as crucial practical embodiments of TCM theoretical frameworks， characterized by their complex multi-component composition and multi-target interactions. The research on the material basis of their pharmacological effects has gradually become the key to promoting the modernization of TCM. In recent years， new ideas and theories regarding the research on pharmacodynamic substance basis of TCM compound prescriptions have been continuously proposed. This review systematically summarizes and reviews analytical techniques such as targeted fishing technology， spectrum-effect relationship analysis， serum pharmacochemistry， network pharmacology， high-throughput screening， and cell membrane chromatography. It is found that these techniques exhibit unique advantages in areas including target-specific analysis， component-pharmacological effect correlation analysis， identification of the material basis in vitro and in vivo， prediction of multi-target mechanisms， efficient screening of active ingredients， and analysis of interactions between cell membrane receptors. These techniques compensate for the shortcomings of traditional research methods， enhance the systematicness and precision of research on pharmacodynamic substance based TCM compound prescriptions， and can provide theoretical support for the promotion and clinical application of TCM compound prescriptions. |
| 期刊： | 2025年第36卷第21期 |
| 作者： | 袁媛；牛娣；庞欣欣；杜朝阳；王亚男；陈瑞芳 |
| AUTHORS： | YUAN Yuan，NIU Di，PANG Xinxin，DU Chaoyang，WANG Yanan，CHEN Ruifang |
| 关键字： | 中药复方；药效物质；分析技术 |
| KEYWORDS： | traditional Chinese medicine compound prescriptions； pharmacodynamic substance； analytical technology |
| 阅读数： | 11 次 |
| 本月下载数： | 0 次 |
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