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壮药鹰不扑（虎刺楤木）的质量标准提升研究
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| 篇名： | 壮药鹰不扑（虎刺楤木）的质量标准提升研究 |
| TITLE： | Improvement of quality standards for Zhuang medicine Yingbupu （Aralia armata） |
| 摘要： | 目的 提升壮药鹰不扑（虎刺楤木）的质量标准。方法以23批鹰不扑（虎刺楤木）为研究对象，观察其外观性状、粉末显微特征；采用薄层色谱法对齐墩果酸与楤木皂苷A进行定性鉴别；参照2020年版《中国药典》（四部）方法测定水分、总灰分、酸不溶性灰分及醇溶性浸出物含量；通过《中药色谱指纹图谱相似度评价系统（2012版）》建立23批样品的超高效液相色谱（UPLC）指纹图谱，并测定齐墩果酸与楤木皂苷A的含量。结果药材粉末显微特征显著，23批药材薄层色谱均能检出齐墩果酸与楤木皂苷A。23批样品中水分、总灰分、酸不溶性灰分和醇溶性浸出物含量范围分别为6.9%～10.4%、1.8%～6.8%、0.1%～1.9%和2.8%～8.4%。根据UPLC指纹图谱，共获得15个共有峰，并指认了其中9个共有峰。23批样品中齐墩果酸、楤木皂苷A的含量范围分别为0.86%～2.69%、0.16%～1.10%。结论本研究新增了鹰不扑（虎刺楤木）药材的水分、总灰分、指纹图谱、薄层鉴别等项目；初步拟定了水分含量不得过11.0%、总灰分含量不得过5.0%、酸不溶性灰分含量不得过2.5%、醇溶性浸出物含量不得低于4.0%以及齐墩果酸、楤木皂苷A的含量分别不得少于1.00%、0.45%（按干燥品计）的质量标准。 |
| ABSTRACT： | OBJECTIVE To improve the quality standard of Zhuang medicine Yingbupu （Aralia armata）. METHODS A total of 23 batches of Yingbupu （A. armata） were studied. Their macroscopic characteristics and powder microscopic features were observed. TLC was employed for the qualitative identification of oleanolic acid and araloside A. Items such as water content， total ash， acid-insoluble ash， and ethanol-soluble extract were determined according to the methods specified in the 2020 edition of the Chinese Pharmacopoeia （part Ⅳ）. UPLC fingerprint was established for 23 batches of samples by using Similarity Evaluation System for Chromatographic Fingerprints of Traditional Chinese Medicine （2012 edition）， and the contents of oleanolic acid and araloside A were determined. RESULTS The powder microscopic characteristics of the medicinal material were distinctive. Oleanolic acid and araloside A were detected by TLC in all 23 batches. Among the 23 batches of samples， the content ranges of moisture， total ash， acid-insoluble ash， and ethanol-soluble extract were 6.9% to 10.4%， 1.8% to 6.8%， 0.1% to 1.9%， and 2.8% to 8.4%， respectively. Based on the UPLC fingerprint， a total of 15 common peaks were obtained， and 9 of these common peaks were identified. The content ranges of oleanolic acid and araloside A in the 23 batches of samples were 0.86% to 2.69% and 0.16% to 1.10%， respectively. CONCLUSIONS This study has added items such as moisture and total ash content fingerprint， TLC identification. A preliminary quality standard has been established for the medicinal material of Yingbupu （A. armata）， stipulating that the moisture content should not exceed 11.0%， the total ash content should not exceed 5.0%， the acid-insoluble ash content should not exceed 2.5%， the ethanol-soluble extract（No. content should not be less than 4.0%， and the contents of zyyzdxk-2023165） oleanolic acid and araloside A should not be less than 1.00% and 0.45%（ calculated by a dried basis）， respectively. |
| 期刊： | 2025年第36卷第21期 |
| 作者： | 赵湘培；粟洁莹；许桃；梁婧；李燕婧；杨梅 |
| AUTHORS： | ZHAO Xiangpei，SU Jieying，XU Tao，LIANG Jing，LI Yanjing，YANG Mei |
| 关键字： | 鹰不扑；虎刺楤木；质量标准；齐墩果酸；楤木皂苷A |
| KEYWORDS： | Yingbupu； Aralia armata； quality standards； |
| 阅读数： | 2 次 |
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