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香连丸治疗溃疡性结肠炎的临床及分子机制研究进展
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| 篇名： | 香连丸治疗溃疡性结肠炎的临床及分子机制研究进展 |
| TITLE： | Research progress on clinical and molecular mechanisms of Xianglian pills in the treatment of ulcerative colitis |
| 摘要： | 溃疡性结肠炎（UC）是一种慢性肠道自身免疫性疾病，以腹痛、腹泻、黏液便和血便等为主要临床表现，发病机制复杂。经典名方香连丸（XLP）近年来被广泛应用于UC的临床治疗，其不良反应较少，患者耐受性好，具有明显临床应用潜力，但其临床研究、分子机制方面的证据尚未得以全面整合。本文通过系统综述XLP在UC治疗中的临床研究及分子机制发现，XLP及其加减方与化学药联用，可显著改善UC患者症状、减轻肠道炎症，效果优于单用化学药。该方改善UC的分子机制涉及调节泛凋亡、免疫反应、相关信号通路（缺氧诱导因子1α、核因子κB等）、肠道菌群和修复肠黏膜屏障等，其组方药材、单体和活性成分还可通过调节Wnt/β-联蛋白、Janus激酶/信号转导及转录活化因子等多条信号通路来阻碍辅助性T细胞17分化，恢复M1/M2型细胞平衡，减轻UC肠道损伤。 |
| ABSTRACT： | Ulcerative colitis （UC） is a chronic intestinal autoimmune disease， with clinical manifestations including abdominal pain， diarrhea， mucus and bloody stools， and its pathogenesis is complex. The classic prescription Xianglian pills （XLP） has been widely used in the clinical treatment of UC in recent years. It has few adverse reactions， good patient tolerance， and shows significant potential for clinical application. However， there is currently no comprehensive integration of evidence on its clinical research and molecular mechanisms. Through a systematic review of the clinical research and molecular mechanisms of XLP in the treatment of UC， it is found that XLP and its modified formulas， when used in combination with chemical drugs， can significantly improve the symptoms of UC patients and reduce intestinal inflammation， with superior efficacy compared to chemical drugs alone. Its mechanism of action involves regulating pan-apoptosis， immune response， signaling pathways （hypoxia-inducible factor-1α， nuclear factor-κB， etc.）， intestinal flora， and repairing the intestinal mucosal barrier. Its medicinal materials， monomers and active components can also prevent the differentiation of helper T cells 17 and restore the balance of M1/M2 cells through regulating multiple pathways such as Wnt/β -catenin and Janus kinase/signal transducer and activator of transcription， thereby reducing intestinal damage in UC. |
| 期刊： | 2025年第36卷第20期 |
| 作者： | 李莹；张早育；邓蓉；陈佳乐；李彦龙 |
| AUTHORS： | LI Ying，ZHANG Zaoyu，DENG Rong，CHEN Jiale，LI Yanlong |
| 关键字： | 香连丸；溃疡性结肠炎；临床研究；分子机制；研究进展 |
| KEYWORDS： | Xianglian pills； ulcerative colitis； clinical research； molecular mechanism； research progress |
| 阅读数： | 10 次 |
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