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仙茅的质量控制现状及质量标志物预测分析
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| 篇名： | 仙茅的质量控制现状及质量标志物预测分析 |
| TITLE： | Quality control status and the prediction analysis of quality markers in Curculigo orchioides |
| 摘要： | 仙茅为石蒜科植物仙茅的干燥根茎，具有抗骨质疏松、抗炎、抗氧化和调节免疫等多种药理作用。然而，仙茅现行质量控制标准主要依赖于单一指标成分（仙茅苷）的含量测定，难以全面反映其质量；同时，炮制方法、采收期、产地等因素也会导致仙茅化学成分种类及含量发生变化。本文基于中药质量标志物理论，从植物亲缘学和化学成分特有性、传统药性、功效、产地和采收期、加工方法、化学成分可测性和入血成分7个方面对仙茅的质量标志物进行预测分析，初步推测可将仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷、仙茅苷乙、仙茅木酚素、β-谷甾醇、actinidioionoside、2，6-二甲氧基苯甲酸、仙茅苷丙、葡萄糖丁香酸、苔黑酚和豆甾醇作为仙茅的质量标志物，为建立仙茅全面系统的质量评价体系提供了科学依据。 |
| ABSTRACT： | Curculigo orchioides refers to the dried rhizome of a plant from Amaryllidaceae family and exhibits a variety of pharmacological activities such as anti-osteoporosis， anti-inflammatory， anti-oxidation and immune regulation. However， the current quality control of C. orchioides mainly relies on the determination of a single indicator component （curculigoside）， which makes it difficult to reflect its quality fully. At the same time， factors such as processing methods， harvesting times， and place of origins can also lead to variations in the types and contents of chemical constituents in C. orchioides. Based on the theory of quality markers （Q-markers） for traditional Chinese medicine， a predictive analysis of the Q-markers of C. orchioides was conducted from seven perspectives： plant phylogeny and specificity of chemical constituents， traditional medicinal properties， efficacy， place of origin and harvesting period， processing methods， measurability of chemical constituents， and blood-entry constituents. It is preliminarily speculated that curculigoside， sakakin， orcinol gentiobioside， curculigoside B， curlignan， β-sitosterol， actinidioionoside， 2，6-dimethoxybenzoic acid， curculigoside C， glucosyringic acid， orcinol and stigmasterol are Q-markers of C. orchioides， providing a scientific basis for establishing a comprehensive and systematic quality evaluation system for C. orchioides. |
| 期刊： | 2025年第36卷第20期 |
| 作者： | 王世聪；王华雨；时博；苗明三 |
| AUTHORS： | WANG Shicong，WANG Huayu，SHI Bo，MIAO Mingsan |
| 关键字： | 仙茅；质量控制；质量标志物；预测 |
| KEYWORDS： | Curculigo orchioides； quality control； quality markers； prediction |
| 阅读数： | 10 次 |
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