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积雪草苷在急性肾损伤中的潜在作用及机制研究进展
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| 篇名： | 积雪草苷在急性肾损伤中的潜在作用及机制研究进展 |
| TITLE： | Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury |
| 摘要： | 急性肾损伤（AKI）是一类以肾功能在短时间内迅速下降为特征的临床综合征，其发病机制涉及氧化应激、炎症反应及细胞程序性死亡等多个环节，且目前缺乏特效治疗药物。现有研究表明，积雪草苷作为天然活性成分，在AKI干预中展现出多靶点保护潜力。其作用机制包括激活核转录因子红系2相关因子2/血红素加氧酶1等抗氧化通路以减轻氧化损伤，调控核因子κB/NOD样受体热蛋白结构域相关蛋白3、Janus激酶2/信号转导和转录激活因子3等关键炎症通路以抑制炎症反应并调节巨噬细胞极化，以及通过影响凋亡相关蛋白表达和激活沉默调节蛋白1-叉头框蛋白O3-人第10号染色体缺失的磷酸酶及张力蛋白同源基因诱导的激酶1-Parkin通路促进线粒体自噬以维持细胞稳态。积雪草苷作为一种多靶点天然化合物，有望为AKI的临床治疗提供新的干预策略，但仍需大样本临床试验验证其疗效及安全性。 |
| ABSTRACT： | Acute kidney injury （AKI） is a clinical syndrome characterized by a rapid decline in renal function within a short period. Its pathogenesis involves multiple processes， including oxidative stress， inflammatory responses， and programmed cell death， while effective pharmacological interventions remain lacking. Current studies have indicated that asiaticoside， a natural active compound， exhibits nephroprotective potential in the intervention of AKI. The potential mechanisms include the activation of antioxidant signaling such as nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 to mitigate oxidative injury， the regulation of key inflammatory pathways including nuclear factor-κB/NOD-like receptor thermal protein domain associated protein 3， and Janus kinase 2/signal transducer and activator of transcription 3 to suppress inflammation and modulate macrophage polarization； it promotes mitophagy by influencing the expression of apoptosis-related proteins and activating the recombinant sirtuin 1-forkhead box-O3-phosphatase and tensin homolog-induced kinase 1-Parkin pathway so as to maintain cellular homeostasis. As a multi-target natural compound， asiaticoside holds promise for providing novel intervention strategies in the clinical treatment of AKI， yet its efficacy and safety still require validation through large-sample clinical trials. |
| 期刊： | 2025年第36卷第19期 |
| 作者： | 周盈盈；章鑫莹；钱盈盈；谢祥成 |
| AUTHORS： | ZHOU Yingying，ZHANG Xinying，QIAN Yingying，XIE Xiangcheng |
| 关键字： | 积雪草苷；急性肾损伤；氧化应激；炎症；自噬；作用机制 |
| KEYWORDS： | asiaticoside； acute kidney injury； oxidative stress； inflammation； autophagy； mechanism of action |
| 阅读数： | 8 次 |
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