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桔梗汤化学成分、药理作用机制及临床应用的研究进展
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| 篇名： | 桔梗汤化学成分、药理作用机制及临床应用的研究进展 |
| TITLE： | Research progress on the chemical constituents，pharmacological mechanisms and clinical application of Jiegeng decoction |
| 摘要： | 桔梗汤是由桔梗和甘草两味中药组成的经典方剂，具有宣肺祛痰、利咽排脓的功效，常用于治疗咳嗽、咽喉肿痛等呼吸道疾病。本文对桔梗汤的化学成分、药理作用机制以及临床应用进行综述，发现桔梗汤含三萜皂苷类、黄酮类、糖苷类、酸类等成分，桔梗皂苷D、桔梗皂苷D2、甘草酸、甘草次酸、甘草素等为主要药效成分；桔梗汤及其化学成分能通过抑制核因子κB、促分裂原活化的蛋白激酶等信号通路发挥抗炎作用，并能通过调节肿瘤免疫微环境、促进癌细胞凋亡等机制发挥抗肿瘤作用，同时还具有抗菌、抗病毒、抗氧化等多种药理作用。桔梗汤及其加减方和复方组合在临床广泛用于治疗咳嗽、肺炎、咽炎等呼吸系统疾病和便秘等消化系统疾病。 |
| ABSTRACT： | Jiegeng decoction is a classic prescription composed of two Chinese medicinal herbs： Platycodon grandiflorum and Glycyrrhiza uralensis. It has the efficacy of diffusing lung qi， resolving phlegm， relieving sore throat and discharging pus， and is commonly used in the treatment of respiratory diseases such as cough and pharyngodynia. This article reviews the chemical components， pharmacological mechanisms and clinical applications of Jiegeng decoction. It was found that Jiegeng decoction contains triterpenoid saponins， flavonoids， glycosides， acids， and other components， with platycodin D， platycodin D2， glycyrrhizic acid， glycyrrhetinic acid， liquiritin， etc.， serving as the main active pharmaceutical ingredients. Jiegeng decoction and its chemical constituents exert anti-inflammatory effects by inhibiting signaling pathways such as nuclear factor-κB and mitogen- activated protein kinases， and demonstrate anti-tumor activities through mechanisms like modulating the tumor immune microenvironment and promoting cancer cell apoptosis. Additionally， it exhibits various pharmacological actions including antibacterial， antiviral， and antioxidant effects. Clinically， Jiegeng decoction， its modified prescription and compound combinations are widely used in the treatment of respiratory diseases such as cough， pneumonia， and pharyngitis， as well as digestive system disorders like constipation. |
| 期刊： | 2025年第36卷第18期 |
| 作者： | 黄云；黄顺旺；乔金为；徐倩；高晓明；鲍学梅；杨满琴；谢若男；蔡明 |
| AUTHORS： | HUANG Yun，HUANG Shunwang， QIAO Jinwei，XU Qian，GAO Xiaoming，BAO Xuemei，YANG Manqin，XIE Ruonan，CAI Ming |
| 关键字： | 桔梗汤；化学成分；药理作用；临床应用 |
| KEYWORDS： | Jiegeng decoction； chemical constituents； pharmacological effects； clinical application |
| 阅读数： | 55 次 |
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