基于四气理论的中药单体对化疗致骨髓抑制的作用机制研究进展
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篇名: 基于四气理论的中药单体对化疗致骨髓抑制的作用机制研究进展
TITLE: Research progress on the mechanism of traditional Chinese medicine monomers acting on myelosuppression after chemotherapy based on the four properties theory
摘要: 化疗是肿瘤的重要治疗手段,但多数患者在化疗后会出现不同程度的骨髓抑制。中医四气理论在改善化疗致骨髓抑制方面具有独特优势,寒性(黄芩、五倍子等)、凉性(女贞子、麦冬等)、温性(人参、淫羊藿、姜黄、当归等)、热性(肉桂、乌头等)、平性(阿胶、枸杞、红景天、真菌)等不同性味的中药,其主要活性单体成分可通过减轻造血干/祖细胞的损伤、改善骨髓造血微环境、抑制氧化应激反应、调控信号通路等,修复炎症损伤,改善造血功能,发挥抗骨髓抑制作用。
ABSTRACT: Chemotherapy is an important treatment for tumors, but most patients experience varying degrees of chemotherapy- induced myelosuppression. Four properties theory of traditional Chinese medicine (TCM) has unique advantages in improving chemotherapy-induced myelosuppression. The monomers from TCM with different properties and flavors, such as cold-natured (e.g. Scutellaria baicalensis, Rhus chinensis), cool-natured (e.g. Ligustrum lucidum, Ophiopogon japonicus), warm-natured (e.g. Panax ginseng, Epimedium brevicornu, Curcuma longa, Angelica sinensis), hot-natured (e.g. Cinnamomum cassia, Aconitum carmichaeli), and neutral-natured (e. g. donkey-hide gelatin, Lycium barbarum, Rhodiola rosea, fungi), can exert anti- myelosuppressive effects by reducing damage to hematopoietic stem/progenitor cells, improving the bone marrow hematopoietic microenvironment, inhibiting the oxidative stress response, regulating signaling pathways, so as to ultimately repaire inflammatory damage and improve hematopoietic function, thereby playing an anti-myelosuppressive role.
期刊: 2025年第36卷第18期
作者: 张思涵;王婷婷;赵志芬;康涵钰;姬佳琦;郭子强;刘潼;蒋士卿
AUTHORS: ZHANG Sihan,WANG Tingting,ZHAO Zhifen,KANG Hanyu,JI Jiaqi,GUO Ziqiang,LIU Tong,JIANG Shiqing
关键字: 中药单体;四气理论;骨髓抑制;化疗;作用机制
KEYWORDS: traditional Chinese medicine monomers; four properties theory; myelosuppression; chemotherapy; mechanism of
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