化疗所致肠黏膜炎的病理机制和治疗策略研究进展
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篇名: 化疗所致肠黏膜炎的病理机制和治疗策略研究进展
TITLE: Research progress on the pathological mechanisms and therapeutic strategies of chemotherapy-induced intestinal mucositis
摘要: 肠黏膜炎是恶性肿瘤化疗引起的常见并发症之一,严重影响化疗效果并降低患者的生存质量。本文系统综述了化疗所致肠黏膜炎的病理机制,涵盖肠道氧化性、炎症性、细胞凋亡性损伤以及肠道屏障受损和肠道菌群失调等多个方面。同时,本文对当前肠黏膜炎的治疗策略进展进行了全面总结,包括化学药物及复合材料、天然药物、中药复方、生长因子、血液制品干预以及粪菌移植等。未来可加强多学科交叉创新,结合动物模型和大样本临床试验,开发高效低毒的治疗药物以平衡化疗的毒性与抗肿瘤疗效。
ABSTRACT: Intestinal mucositis is a common complication induced by chemotherapy in malignant tumors, which severely compromises the efficacy of chemotherapy and reduces patients’ quality of life. This article systematically reviews the pathological mechanisms underlying chemotherapy-induced intestinal mucositis, encompassing oxidative damage, inflammatory injury, apoptotic damage, disruption of the intestinal barrier, and intestinal dysbiosis. Additionally, it provides a comprehensive summary of current therapeutic strategies for intestinal mucositis, including chemical agents and composite materials, natural products, compound prescription of traditional Chinese medicine, growth factors, blood products, and fecal microbiota transplantation. Future efforts should strengthen multidisciplinary cross-innovation, integrating animal models and large-scale clinical trials to develop highly effective and low-toxicity therapeutic drugs that balance chemotherapy toxicity and antitumor efficacy.
期刊: 2025年第36卷第17期
作者: 晏晓晨;王宗奎;叶生亮
AUTHORS: YAN Xiaochen,WANG Zongkui,YE Shengliang
关键字: 肠黏膜炎;化疗;病理机制;治疗策略;研究进展
KEYWORDS: intestinal mucositis; chemotherapy; pathological mechanisms; therapeutic strategies; research progress
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