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美罗培南治疗药物监测中国专家共识
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| 篇名： | 美罗培南治疗药物监测中国专家共识 |
| TITLE： | Chinese expert consensus for therapeutic drug monitoring of meropenem |
| 摘要： | 目的 规范美罗培南治疗药物监测（TDM）的实施方法，确保TDM的结果准确，以助力科学制定美罗培南的个体化治疗方案。方法本专家共识由中国药师协会治疗药物监测药师分会发起，编写组涵盖了临床药学、TDM技术和药事管理专家，按照世界卫生组织指南制定手册和TDM指南制订的相关建议制定。编写组通过3轮德尔菲投票，选出12个临床问题，通过数据库检索相关的原始文章、系统综述和指南，并采用GRADE方法评估质量后制定共识建议；再根据专家组意见进行整理修订，最终形成本共识。结果形成了14条推荐意见，涵盖治疗美罗培南TDM全过程，主要包括TDM的必要性、检测方法、监测时机、目标药动学/药效学参数，以及基于药动学/药效学的剂量调整以及TDM的质量控制。结论本共识为我国医疗机构美罗培南TDM的实施提供了规范化的方法与流程建议，对美罗培南个体化用药方案的制订、临床疗效的提高、用药安全的保障具有重要意义。 |
| ABSTRACT： | OBJECTIVE To standardize the implementation methods for therapeutic drug monitoring （TDM） of meropenem and ensure the accuracy of TDM results， thereby facilitating the scientific development of individualized treatment regimens for meropenem. METHODS The expert consensus was launched by the Society of Therapeutic Drug Monitoring Pharmacists of Chinese Pharmacists Association. The compilation team comprised experts in clinical pharmacy， TDM technology， and pharmaceutical administration， and it was developed in accordance with the relevant recommendations from the methodology handbook of WHO and the guidelines for TDM guidelines development. Twelve clinical questions were selected through a three- round Delphi voting process conducted by the committee， followed by a comprehensive review of relevant original articles， systematic reviews， and guidelines through general databases. The GRADE approach was employed to evaluate the quality of evidence so as to formulate the consensus recommendations. The experts’ opinions were organized， revised and finally formed into a consensus. RESULTS Ultimately， the consensus presented 14 recommendations， mainly regarding all aspects of TDM processes including necessity， method， monitor timing， target PK/PD， medication adjustments based on PK/PD， and the quality control of TDM. CONCLUSIONS This consensus provides standardized methods and process suggestions for meropenem TDM in medical institutions in China， and is of great significance for meropenem individualized drug use， improving clinical efficacy， and ensuring drug safety. |
| 期刊： | 2025年第36卷第16期 |
| 作者： | 《美罗培南治疗药物监测中国专家共识》编写组；中国药师协会治疗药物监测药师分会 |
| AUTHORS： | Writing Group of the Chinese Expert Consensus for Therapeutic Drug Monitoring of Meropenem，Society of Therapeutic Drug Monitoring Pharmacists of Chinese Pharmacists Association |
| 关键字： | 美罗培南；治疗药物监测；药动学；药效学；专家共识 |
| KEYWORDS： | meropenem； therapeutic drug monitoring； pharmacokinetics； pharmacodynamics； expert consensus |
| 阅读数： | 5 次 |
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