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基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价标准
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| 篇名： | 基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价标准 |
| TITLE： | Construction of drug utilization evaluation criteria for Dezocine injection based on evidence-based methodology and Delphi method |
| 摘要： | 目的 构建地佐辛注射液的药物利用评价标准，为医疗机构合理用药提供参考。方法以循证方法学为基础，查阅相关指南/专家共识、系统评价/Meta分析，筛选证据后，初步建立地佐辛注射液的评价标准框架。采用德尔菲法，选择28位来自天津、北京、山东等8个省份的二级及以上级别医疗机构的临床医师和临床药师，进行2轮问卷调查，根据专家积极系数、权威系数及协调程度等确定最终指标。结果2轮问卷有效回收率分别为100%和92.86%；2轮专家权威系数分别为0.82、0.81，专家协调程度分别为0.29、0.31（P＜0.001）。最终形成包含用药指征、用药过程和用药结果三大维度，涵盖11个一级指标（如适应证、用法用量等）和33个二级指标（如分娩镇痛、中大手术后重度疼痛镇痛应与其他镇痛药联合应用等）的地佐辛注射液药物利用评价标准体系，各指标的重要性评分均值为4.08～5.00分，总体评分均值为4.61分，变异系数为0～0.19。结论基于循证方法学和德尔菲法建立的地佐辛注射液药物利用评价标准具有较好的权威性和科学性，为后续临床用药合理性评价提供了参考依据。 |
| ABSTRACT： | OBJECTIVE To construct the drug utilization evaluation criteria for Dezocine injection， so as to provide reference for the rational drug use in medical institutions. METHODS On the basis of evidence methodology， relevant guidelines/expert consensus， systematic reviews/meta-analysis were consulted； the evaluation criteria framework for Dezocine injection was established after screening evidence. Delphi method was employed， whereby 28 clinicians and clinical pharmacists from secondary and above-level medical institutions across eight provinces， including Tianjin， Beijing and Shandong， were selected to participate in two rounds of questionnaire surveys. The final indicators were determined based on the experts’ enthusiasm coefficient， authority coefficient， and degree of coordination. RESULTS The effective recovery rate of questionnaire was 100% in the first round and 92.86% in the second round； expert authority coefficient was 0.82 in the first round and 0.81 in the second round； the coordination degree of experts in the first round was 0.29， and in the second round was 0.31 （P＜0.001）. Drug utilization evaluation standard system for Dezocine injection was formed finally， including three dimensions of medication indications， medication process and medication results， with a total of 11 first-level indicators （such as indications， usage and dosage） and 33 second-level indicators （such as labor analgesia and the management of severe pain following major or moderate surgeries combined with other analgesic drugs）. The average importance scores for each indicator ranged from 4.08 to 5.00 points， with an overall average score of 4.61 points and coefficient of variation ranging from 0 to 0.19. CONCLUSIONS The drug utilization evaluation criteria for Dezocine injection established based on evidence-based methodology and Delphi method is authoritative and scientific， which provides a reference for subsequent evaluation of the rationality of clinical medication. |
| 期刊： | 2025年第36卷第15期 |
| 作者： | 郭媛媛；王超；秦寅鹏；张弋；卜一珊 |
| AUTHORS： | GUO Yuanyuan，WANG Chao，QIN Yinpeng，ZHANG Yi，BU Yishan |
| 关键字： | 地佐辛注射液；药物利用；评价标准；循证方法学；德尔菲法 |
| KEYWORDS： | Dezocine injection； drug utilization； evaluation criteria； evidence-based methodology； Delphi method |
| 阅读数： | 4 次 |
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