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非编码RNA对骨关节炎的调控机制及中药干预研究进展
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| 篇名： | 非编码RNA对骨关节炎的调控机制及中药干预研究进展 |
| TITLE： | Regulatory mechanism of non-coding RNA in osteoarthritis and the research on traditional Chinese medicine intervention |
| 摘要： | 骨关节炎（OA）是一种以关节软骨退变为核心病理特征的慢性退行性疾病，其发病机制涉及炎症反应、软骨细胞凋亡及细胞外基质（ECM）降解等。非编码RNA（ncRNA）凭借其多样化的调控途径参与OA的发生发展，为其治疗提供了新的潜在靶点。本文系统阐述了ncRNA[微小ncRNA（miR）、环状ncRNA（circR）、长链ncRNA（lncR）]调控OA的作用机制及中药通过调控ncRNA干预OA的研究现状。结果显示，ncRNA通过构建多层次调控网络参与OA的病理进程：miR靶向关键基因的翻译抑制，调控下游信号通路；circR既可作为“分子海绵”竞争性吸附miR间接参与调控，又能直接调节蛋白功能；lncR兼具“分子海绵”作用和直接通路干预能力。穿心莲内酯、新风胶囊等通过调节miR的表达，形成“中药-miR-下游反应链”，以减少基质水解酶表达、抑制炎症因子分泌等途径干预OA进程；芍药苷、荣筋拈痛方等通过影响circR和lncR，形成“中药-lncR/circR-miR-下游反应链”，以促进软骨细胞增殖，减少ECM降解等途径干预OA进程。 |
| ABSTRACT： | Osteoarthritis （OA） is a chronic degenerative disease characterized primarily by the degeneration of articular cartilage， with its pathogenesis involving a multifactorial interplay of inflammatory responses， chondrocyte apoptosis， and extracellular matrix （ECM） degradation. Non-coding RNA （ncRNA） participates in the occurrence and development of OA through their diverse regulatory pathways， providing new potential targets for its treatment. This paper systematically elucidates the mechanisms of ncRNA [micro ncRNA （miR）， circular ncRNA （circR）， and long ncRNA （lncR）] in regulating OA ， as well as the current research status of traditional Chinese medicine （TCM） intervening in OA by modulating ncRNA. It is found that ncRNA participate in the pathological processes of OA by constructing a multi-layered regulatory network： miR inhibits the translation of key target genes and regulate downstream signaling pathways； circR can act as ‘molecular sponges’ to competitively absorb miRs for indirect regulation， as well as directly modulate protein functions； lncR possess both ‘molecular sponge’ capabilities and the ability to intervene directly in pathways. Andrographolide， Xinfeng capsules and others intervene in the OA process by regulating the expression of miR， forming a ‘TCM-miR-downstream response chain’， which reduces the expression of matrix-hydrolyzing enzymes and inhibits the secretion of inflammatory factors； paeoniflorin， Rongjin niantong formula and others intervene in the OA process by affecting circR and lncR， thereby forming a ‘TCM-lncR/circR-miR-downstream response chain’ to promote chondrocyte proliferation and reduce ECM degradation. |
| 期刊： | 2025年第36卷第14期 |
| 作者： | 黄范焯；黎缘；张璇；刘渊 |
| AUTHORS： | HUANG Fanzhuo，LI Yuan，ZHANG Xuan，LIU Yuan |
| 关键字： | 骨关节炎；中药；复方；非编码RNA；调控机制 |
| KEYWORDS： | osteoarthritis； traditional Chinese medicine； compound formula； non-coding RNA； regulatory mechanism |
| 阅读数： | 11 次 |
| 本月下载数： | 0 次 |
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