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中药调控NF-κB信号通路防治心肌梗死的研究进展
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| 篇名： | 中药调控NF-κB信号通路防治心肌梗死的研究进展 |
| TITLE： | Research progress on the prevention and treatment of myocardial infarction by traditional Chinese medicine through regulating NF-κB signaling pathway |
| 摘要： | 心肌梗死（MI）是指由于冠状动脉血流急剧减少或中断，引起心肌因持久性缺血缺氧而发生坏死的一种急性临床综合征。核因子κB（NF-κB）是诱导炎症反应的枢纽，也是参与促炎因子和心肌细胞凋亡的关键。本文系统阐述了NF-κB信号通路在MI中的作用机制，并综述中药有效成分及复方调控该信号通路防治MI的研究现状，结果显示中药有效成分（人参皂苷Rg3、黄芩素、姜黄素、丹参酮ⅡA、藤黄酸等）及复方（芪苈强心胶囊、益气活血汤、灵宝护心丹、丹红注射液、保元汤合桃红四物汤）能够通过抑制NF-κB信号通路改善心肌纤维化、减轻炎症反应、抑制心肌细胞凋亡，从而达到防治MI的目的。 |
| ABSTRACT： | Myocardial infarction （MI） refers to an acute clinical syndrome of myocardial necrosis due to persistent ischemia and hypoxia， resulting from the sharp reduction or interruption of coronary blood flow. Nuclear factor κB （NF-κB） is the key factor in inducing inflammatory response， and it is involved in the production of pro-inflammatory factors and myocardial cell apoptosis. This article systematically describes the molecular regulation mechanism of the NF-κB signaling pathway in MI， and reviews the related research on the prevention and treatment of MI through the regulation of this signaling pathway by active ingredients and compound formulas from traditional Chinese medicine （TCM）. It has been found that active ingredients from TCM， such as ginsenoside Rg3， baicalein， curcumin， tanshinone ⅡA， gambogic acid， as well as compound formulas， including Qili qiangxin capsules， Yiqi huoxue decoction， Lingbao huxin dan， Danhong injection， Baoyuan decoction combined with Taohong siwu decoction， can improve myocardial fibrosis， alleviate inflammatory responses， and inhibit cardiomyocyte apoptosis by suppressing the NF-κB signaling pathway. Thereby， they achieve the goal of preventing and treating MI. |
| 期刊： | 2025年第36卷第14期 |
| 作者： | 郑力榕；杨培丽；李桂伟；郭俊池；赵英强 |
| AUTHORS： | ZHENG Lirong，YANG Peili，LI Guiwei，GUO Junchi，ZHAO Yingqiang |
| 关键字： | 心肌梗死；核因子-κB；中药；有效成分；复方 |
| KEYWORDS： | myocardial infarction； NF-κB； traditional Chinese medicine； active ingredients； compound formula |
| 阅读数： | 12 次 |
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