JAK2/STAT3信号通路在脑缺血再灌注损伤中的作用及中药干预研究进展
x

请在关注微信后,向客服人员索取文件

篇名: JAK2/STAT3信号通路在脑缺血再灌注损伤中的作用及中药干预研究进展
TITLE: Research progress on the role of JAK2/STAT3 signaling pathway in cerebral ischemia-reperfusion injury and TCM intervention
摘要: Janus激酶2(JAK2)/信号转导及转录活化因子3(STAT3)信号通路可调控神经元生长、发育、增殖、分化等多个过程,与脑缺血再灌注损伤(CIRI)的发生、发展及治疗密切相关。本文在概述JAK2/STAT3信号通路及其与CIRI关系的基础上,综述了中药调控JAK2/STAT3信号通路改善CIRI的研究现状。其中,甘草次酸、雷公藤内酯醇、桃红四物汤等中药单体及复方可通过抑制JAK2/STAT3信号通路来抑制炎症反应、增强细胞自噬、抑制细胞凋亡,从而减轻CIRI;黄芪甲苷、银杏内酯K、清脑滴丸等中药单体及复方可通过激活JAK2/STAT3信号通路来抑制氧化应激、促进血管新生、提高神经元存活率,从而改善CIRI。
ABSTRACT: Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling pathway regulates multiple processes in neurons, including growth, development, proliferation and differentiation, and is closely associated with the onset, progression and treatment of cerebral ischemia-reperfusion injury (CIRI). This article provides an overview of the JAK2/ STAT3 signaling pathway and its relationship with CIRI, followed by a comprehensive review of the current research status on the regulation of the JAK2/STAT3 signaling pathway by traditional Chinese medicine (TCM) to ameliorate CIRI. Among them, TCM monomers and compound prescriptions such as glycyrrhetinic acid, triptolide, and Taohong siwu decoction can inhibit inflammatory responses, enhance cellular autophagy, and suppress apoptosis by inhibiting the JAK2/STAT3 signaling pathway, thereby alleviating CIRI. In addition, TCM monomers and compound prescriptions like astragaloside Ⅳ, ginkgolide K, and Qingnao dripping pills can mitigate CIRI by activating the JAK2/STAT3 signaling pathway to inhibit oxidative stress, promote angiogenesis, and enhance neuronal survival rates.
期刊: 2025年第36卷第12期
作者: 陶志娟;周琴宜;张璋
AUTHORS: TAO Zhijuan,ZHOU Qinyi,ZHANG Zhang
关键字: 中药;脑缺血再灌注损伤;JAK2/STAT3信号通路;机制
KEYWORDS: traditional Chinese medicine; cerebral ischemia-reperfusion injury; JAK2/STAT3 signaling pathway; mechanism
阅读数: 7 次
本月下载数: 0 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!