中药通过线粒体质量控制改善心肌缺血再灌注损伤的机制研究进展
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篇名: | 中药通过线粒体质量控制改善心肌缺血再灌注损伤的机制研究进展 |
TITLE: | Research progress on mechanism of traditional Chinese medicine in improving myocardial ischemia-reperfusion injury by mitochondrial quality control |
摘要: | 心肌缺血再灌注损伤(MIRI)是常见的心脏病理过程,是代谢变化、线粒体功能障碍等多种机制共同作用的结果。线粒体质量控制(MQC)作为关键的调控机制,可能是防治MIRI的重要靶点。近年来,中药在改善MIRI领域表现出多靶点、多途径、低毒副作用的独特优势,已得到临床的普遍认可并得以应用。本文通过对近年来中药单体、有效部位、药对、复方及相关制剂等靶向MQC改善MIRI的相关研究进行系统整理、归纳后发现,中药单体及有效部位(五味子乙素、异甘草素、金盏花苷E、小檗碱、枸杞多糖等),中药药对、复方及相关制剂(附子-干姜、益心方、双参宁心胶囊、白金方、益气活血药方等)可通过激活MQC以减少氧化应激损伤、促进线粒体生物发生、维持线粒体分裂/融合稳态、调节线粒体自噬、恢复线粒体钙稳态等途径来减轻MIRI。 |
ABSTRACT: | Myocardial ischemia-reperfusion injury (MIRI) is a common cardiac pathological process, resulting from the combined effects of multiple mechanisms involving metabolic changes and mitochondrial dysfunction. Mitochondrial quality control (MQC), as a key regulatory mechanism, may serve as an important target for the prevention and treatment of MIRI. In recent years, traditional Chinese medicine (TCM) has demonstrated unique advantages in the field of improving MIRI, with multiple targets, multiple pathways, and low toxic and side effects. It has gained widespread clinical recognition and application. Through systematically organizing and summarizing recent studies on the targeting of MQC by monomers, active fractions, herb pairs, compound formulas and related preparations of TCM to improve MIRI, this paper finds that monomers and active fractions of TCM (such as schisandrin B, isoliquiritigenin, calenduloside E, berberine, Lycium barbarum polysaccharides and so on) as well as TCM herb pairs, compound formulas, and related preparations (couplet medicinals of Fuzi-Ganjiang, Yixin formula, Shuangshen ningxin capsule, Baijin formula, Yiqi huoxue decoction and so on), can alleviate MIRI by activating MQC to reduce oxidative stress-induced damage, promote mitochondrial biogenesis, maintain mitochondrial fission/fusion homeostasis, regulate mitochondrial autophagy, and restore mitochondrial calcium homeostasis. |
期刊: | 2025年第36卷第12期 |
作者: | 张高静;袁智宇;刘新灿;孙天福;兰真真 |
AUTHORS: | ZHANG Gaojing,YUAN Zhiyu,LIU Xincan,SUN Tianfu,LAN Zhenzhen |
关键字: | 中药;心肌缺血再灌注损伤;线粒体质量控制 |
KEYWORDS: | traditional Chinese medicine; myocardial ischemia-reperfusion injury; mitochondrial quality control |
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