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中药调控Nrf2信号通路改善脓毒症肺损伤的作用机制研究进展
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| 篇名： | 中药调控Nrf2信号通路改善脓毒症肺损伤的作用机制研究进展 |
| TITLE： | Research progress on the mechanism of action of traditional Chinese medicine regulating Nrf2 signaling pathway to improve sepsis-induced lung injury |
| 摘要： | 脓毒症肺损伤是脓毒症并发多器官功能障碍综合征中极为常见的一种，炎症反应和氧化应激失衡是其关键的病理机制。核转录因子红系2相关因子2（Nrf2）信号通路作为抗炎、抗氧化应激的重要通路，在脓毒症肺损伤的发生发展过程中具有重要作用。本文通过对近10年内中药调控Nrf2信号通路改善脓毒症肺损伤的相关研究进行综述的结果显示，14种中药有效成分（包括黄酮类、萜类、生物碱类、皂苷类、酚类5类化合物）、6种中药复方（包括清热解毒、通里攻下、扶正固本3类方剂）能够通过激活Nrf2信号通路及干预Kelch样ECH关联蛋白1、血红素加氧酶1、抗氧化响应元件、腺苷一磷酸活化的蛋白激酶等相关通路来抑制炎症反应和氧化应激，从而减轻脓毒症肺损伤。 |
| ABSTRACT： | Sepsis-induced lung injury is a common type of sepsis complicated with multiple organ dysfunction syndrome， whose uncontrolled inflammatory response and oxidative stress are the key pathological mechanisms. As an important pathway of anti-inflammatory and anti-oxidative stress， the nuclear factor-erythroid 2-related factor 2 （Nrf2） signaling pathway is very important in the occurrence and development of sepsis-induced lung injury. This review summarizes relevant research conducted over the past decade on the regulation of the Nrf2 signaling pathway by traditional Chinese medicine （TCM） to ameliorate sepsis- induced lung injury. It has been found that 14 kinds of TCM effective ingredients （including five types of compounds： flavonoids， terpenes， alkaloids， saponins， phenols） and 6 kinds of compound preparations （including three types of formulas： heat-clearing and detoxifying formulas， purgative formulas for promoting bowel movement， and formulas for reinforcing vital qi and consolidating the constitution） can inhibit inflammatory responses and oxidative stress by activating Nrf2 signaling pathway and intervening in related pathways such as those involving Kelch-like ECH-associated protein 1， heme oxygenase-1， antioxidant response element and AMP-activated protein kinase， thereby alleviating sepsis-induced lung injury. |
| 期刊： | 2025年第36卷第12期 |
| 作者： | 李洋；张瑞芬；贾婷婷；张海荣；赵建；黄新生；李晓；钟鑫 |
| AUTHORS： | LI Yang， ZHANG Ruifen，JIA Tingting，ZHANG Hairong，ZHAO Jian，HUANG Xinsheng，LI Xiao，ZHONG Xin |
| 关键字： | 中药；有效成分；复方；脓毒症；肺损伤；Nrf2信号通路 |
| KEYWORDS： | traditional Chinese medicine； effective ingredients； compound preparations； sepsis； lung injury； Nrf2 signaling |
| 阅读数： | 4 次 |
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