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乳腺癌靶向PI3K/Akt/mTOR抑制剂合理用药管理专家共识
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| 篇名： | 乳腺癌靶向PI3K/Akt/mTOR抑制剂合理用药管理专家共识 |
| TITLE： | Expert consensus on rational medication management of targeted PI3K/Akt/mTOR inhibitors in breast cancer |
| 摘要： | 目的 为规范磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂在乳腺癌治疗中的合理使用，为药师开展同质化药物治疗管理提供参考。方法采用名义群体法，由内容专家（临床医学、药学）和方法学专家（循证医学、统计学、医学伦理学）组成多学科编写团队，通过系统检索、分析、归纳制定共识初稿。采用问卷方式收集外审专家审阅意见，对专家意见进行修改，形成本共识定稿。结果本共识以PI3K/Akt/mTOR抑制剂的药物治疗管理全过程为主线，包含信息收集、治疗方案评估、药学干预模块，重点针对疗效评估、药物选择、安全性、相互作用和依从性提出7个临床问题并形成8项推荐意见。结论本共识为药师开展PI3K/Akt/mTOR抑制剂用于乳腺癌的治疗管理提供了全面指导，有助于提高患者治疗效果，降低不良反应发生率，确保患者用药安全有效。 |
| ABSTRACT： | OBJECTIVE To promote the rational use of phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/ mammalian target of rapamycin （mTOR） inhibitors in breast cancer treatment and provide guidance for pharmacists to implement homogeneous medication therapy management. METHODS A multidisciplinary panel comprising content experts （clinical medicine， pharmacy） and methodological experts （evidence-based medicine， statistics， medical ethics） was assembled using the Nominal Group Technique. A draft consensus was developed through systematic literature retrieval， analysis， and synthesis. External reviewers evaluated the draft via questionnaire-based feedback and revisions were incorporated to finalize the consensus. RESULTS This consensus framework focuses on the medication therapy management process of PI3K/Akt/mTOR inhibitors with information collection， treatment regimen evaluation and pharmaceutical intervention structure modules. Seven critical issues and eight evidence-based recommendations were addressed， including efficacy assessment， drug selection， safety， drug interactions， and adherence. CONCLUSION This consensus offers comprehensive medication guidance on PI3K/Akt/mTOR inhibitors in the treatment of breast cancer for pharmacists， aiming to enhance therapeutic effectiveness in patients， reduce the incidence of adverse reactions， and ensure the safe and effective use of medications. |
| 期刊： | 2025年第36卷第11期 |
| 作者： | 《乳腺癌靶向PI3K/Akt/mTOR抑制剂合理用药管理专家共识》编写组 |
| AUTHORS： | Writing Group of Expert Consensus on Rational Medication Management of Targeted PI3K/Akt/mTOR Inhibitors in Breast Cancer |
| 关键字： | 磷脂酰肌醇3激酶；蛋白激酶B；哺乳动物雷帕霉素靶蛋白；信号通路抑制剂；乳腺癌；用药指导；药学监护 |
| KEYWORDS： | phosphatidylinositol-3-kinase； protein kinase B； mammalian target of rapamycin； pathway inhibitors； breast |
| 阅读数： | 6 次 |
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