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远志配伍对砂烫马钱子的减毒增效作用研究
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| 篇名： | 远志配伍对砂烫马钱子的减毒增效作用研究 |
| TITLE： | Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica |
| 摘要： | 目的 探究远志配伍对砂烫马钱子（简称“砂马”）毒性和抗炎、镇痛药效的影响。方法制备砂马单煎液、砂马-去芯远志1∶2.5或1∶5共煎液[简称“砂马远志（1∶2.5）共煎液”或“砂马远志（1∶5）共煎液”]和砂马-去芯远志（1∶5）混合液[简称“砂马远志（1∶5）混合液”]，考察其半数致死剂量（LD50）；以阿司匹林为阳性对照，比较上述药液致小鼠扭体次数、镇痛率、疼痛潜伏期、耳肿胀度、炎症抑制率的不同；检测上述药液中活性兼毒性成分士的宁、马钱子碱的含量。结果砂马单煎液、砂马远志（1∶2.5）共煎液、砂马远志（1∶5）共煎液、砂马远志（1∶5）混合液的LD50分别为302.00、614.47、1445.44、1778.28mg/kg；上述药液组小鼠的扭体次数、耳肿胀度均较对照组显著减少或降低（P＜0.05或P＜0.01），疼痛潜伏期[砂马单煎液组90、120min时，砂马远志（1∶2.5）共煎液组60、90min时以及砂马远志（1∶5）共煎液组和砂马远志（1∶5）混合液组60、90、120min时]均较对照组显著延长（P＜0.05或P＜0.01）；各药液的镇痛率分别为39.30%、70.87%、80.00%、82.46%，炎症抑制率分别为38.08%、57.89%、76.47%、50.46%，且共煎液、混合液的镇痛、抗炎效果普遍优于单煎液（P＜0.05或P＜0.01）。上述4种药液中，士的宁的总含量分别为0.71%、0.42%、0.47%、0.64%，马钱子碱的总含量分别为0.88%、0.63%、0.57%、0.88%。结论远志配伍能减轻砂马的毒性，并可增强砂马的抗炎、镇痛活性，其增效减毒作用有随远志用量增加而增强的趋势；且两者共煎可降低砂马中活性兼毒性成分士的宁、马钱子碱的含量。 |
| ABSTRACT： | OBJECTIVE To explore the effects of Polygala tenuifolia compatibility on toxicity， anti-inflammatory and analgesic efficacy of sand-ironing Strychnos nux-vomica （SS）. METHODS The preparation of SS single decoction， SS-P. tenuifolia core-removed （PC） （1∶2.5） or （1∶5） combined decoction， and SS-PC （1∶5） mixture were carried out to investigate their median lethal dose （LD50）. Using aspirin as positive control， the number of writhing movements， analgesic rate， pain latency， ear swelling degree and inflammation inhibition rate induced by the above-mentioned medicinal liquids in mice were compared. The contents of the active and toxic components， strychnine and brucine， in the above-mentioned medicinal liquids were also determined. RESULTS The LD50 values of SS single decoction， SS-PC （1∶2.5） combined decoction， SS-PC （1∶5） combined decoction and SS- PC （1∶5） mixture were 302.00， 614.47， 1 445.44 and 1 778.28 mg/kg， respectively. Compared with control group， the number of writhing movements and ear swelling degree in the mice of the above-mentioned medicinal liquid groups were reduced or decreased significantly （P＜0.05 or P＜0.01）； pain latency [at 90 and 120 minutes in the SS single decoction group， at 60 and 90 minutes in the SS-PC （1∶2.5） combined decoction group， and at 60，90， 120 minutes in the SS-PC （1∶5） combined decoction group and SS-PC （1∶5） mixture group] was significantly prolonged （P＜0.05 or P＜0.01）； analgesic rates of the respective medicinal liquids were 39.30%， 70.87%， 80.00% and 82.46%， and inflammation inhibition rates were 38.08%，TD 57.89%， 76.47% and 50.46%； analgesic and anti-inflammatory effects of combined decoction and mixture were generally better than those of the single decoction （P＜0.05 or P＜0.01）. In the above-mentioned four medicinal liquids， the total contents of strychnine were 0.71%， 0.42%， 0.47% and 0.64%， and the total contents of brucine were 0.88%， 0.63%， 0.57% and 0.88%， respectively. CONCLUSIONS The combination of P. tenuifolia can reduce the toxicity of SS and enhance its anti-inflammatory and analgesic effects. Moreover， there is a tendency for the toxicity-reducing and efficacy-enhancing effects to increase with the increasing dosage of P. tenuifolia. Additionally， the combined decoction of SS and P. tenuifolia can reduce the contents of the active and toxic components， strychnine and brucine， in SS. |
| 期刊： | 2025年第36卷第10期 |
| 作者： | 隋怡；冯果；刘刚；柳克艳；韦学浩；滕明刚；李玮；韩彩瑶；雷燕 |
| AUTHORS： | SUI Yi，FENG Guo，LIU Gang，LIU Keyan，WEI Xuehao，TENG Minggang，LI Wei，HAN Caiyao，LEI Yan |
| 关键字： | 砂烫马钱子；远志；减毒增效；急性毒性；抗炎；镇痛；士的宁；马钱子碱 |
| KEYWORDS： | sand-ironing Strychnos nux-vomica； Polygala tenuifolia； toxicity-reducing and efficacy-enhancing effects； acute |
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