姜黄素抗抑郁作用机制的研究进展
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篇名: | 姜黄素抗抑郁作用机制的研究进展 |
TITLE: | Research progress on mechanism of antidepressant action of curcumin |
摘要: | 姜黄素是一种天然黄色色素,是从姜黄、莪术等姜科植物根茎中提取得到的一种天然酚类抗氧化剂,具有抗炎、抗肿瘤、抗氧化等特性。近年来研究发现,姜黄素还具有良好的抗抑郁特性,其被认为是一种安全有效的抗抑郁潜在药物。姜黄素抗抑郁的药效作用机制主要包括调节神经递质、调节下丘脑-垂体-肾上腺轴、调节脑源性神经营养因子、抑制神经炎症、抑制氧化应激以及调节肠道菌群等,且上述机制存在相互关联和叠加效应。目前,姜黄素的抗抑郁作用机制仍未完全明晰,未来需结合多组学技术、新型制剂技术、临床试验以获得进一步突破。 |
ABSTRACT: | Curcumin is a natural yellow pigment, a natural phenolic antioxidant extracted from the rhizomes of Curcuma longa and Curcumae Rhizoma of the ginger family, with anti-inflammatory, anti-tumor and antioxidant properties. In recent years, it has been found that curcumin also has good antidepressant properties, and it is considered a safe and effective antidepressant potential drug. The mechanism of curcumin’s antidepressant efficacy mainly includes regulating neurotransmitters, modulating the hypothalamic-pituitary-adrenal axis, regulating brain-derived neurotrophic factor, inhibiting neuroinflammation, inhibiting oxidative stress, and regulating gut microbiota, etc., and there is an overlapping and synergistic therapeutic effect of the above mechanisms. At present, the antidepressant mechanism of curcumin is still not fully understood, and will be combined with multi-omics technology, new formulation technology, and clinical trials to obtain further breakthroughs in the future. |
期刊: | 2025年第36卷第09期 |
作者: | 周建平;席雨婷;付皓;周策 |
AUTHORS: | ZHOU Jianping,XI Yuting,FU Hao,ZHOU Ce |
关键字: | 姜黄素;抑郁症;神经递质;炎症反应;氧化应激;作用机制 |
KEYWORDS: | curcumin; depression; neurotransmitter; inflammatory response; oxidative stress; mechanism |
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