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中药调控PI3K/Akt信号通路促进慢性创面愈合的研究进展
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| 篇名： | 中药调控PI3K/Akt信号通路促进慢性创面愈合的研究进展 |
| TITLE： | Research progress of traditional Chinese medicine regulating PI3K/Akt signaling pathway to promote chronic wound healing |
| 摘要： | 慢性创面愈合的发病机制十分复杂，这类创伤通常伴随着较长的病程和较大的治疗难度，导致愈合困难，严重影响患者的生活质量。中药有效成分、药对及复方在治疗慢性创面愈合上具有独特优势。磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路通过调控细胞凋亡、血管生成及炎症反应等一系列生物学过程在治疗慢性创面愈合方面极其关键。本文对中药调控PI3K/Akt信号通路促进慢性创面愈合的相关研究进行综述，发现中药有效成分（如京尼平苷、黄芪甲苷、人参皂苷等）及复方（如冲和膏、黄连膏、湿润烧伤膏等）主要通过激活PI3K/Akt信号通路来降低炎症反应、促进血管生成、调节细胞自噬，进而加速创面愈合；同时也有少数中药如药对（如黄芪-红花）、复方（如象皮生肌膏）通过抑制该信号通路发挥抗炎作用，促进创面愈合。 |
| ABSTRACT： | The pathogenesis of chronic wound healing is complex. It is often difficult to heal due to a long course of disease， difficulty in treatment， and it seriously affects the quality of life in patients. The active ingredients， couplet medicinals， and compound formulas of traditional Chinese medicine （TCM） possess unique advantages in the treatment of chronic wound healing. The phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway is extremely critical in the treatment of chronic wound healing by regulating a series of biological processes， including cell apoptosis， angiogenesis， and inflammatory responses. This article reviews the relevant research on the regulation of the PI3K/Akt signaling pathway by TCM to promote chronic wound healing. It has been found that the active ingredients of TCM （such as geniposide， astragaloside， and ginsenosides， etc.）， and compound formulas （such as Chonghe ointment， Huanglian ointment， Shirun shaoshang ointment， etc.） mainly reduce inflammatory responses， promote angiogenesis， regulate cell autophagy， and accelerate wound healing by activating the PI3K/Akt signaling pathway； at the same time， there are also a few couplet medicinals（ such as Huangqi-Honghua） and compound formulas （such as Xiangpi Shengji ointment） that exert anti-inflammatory effects by inhibiting this signaling pathway， to promote wound healing. |
| 期刊： | 2025年第36卷第08期 |
| 作者： | 朱振辉；李志；冷羽；蔡涛；申学发；向先雪；黄永新 |
| AUTHORS： | ZHU Zhenhui，LI Zhi，LENG Yu，CAI Tao，SHEN Xuefa，XIANG Xianxue，HUANG Yongxin |
| 关键字： | 中药；活性成分；药对；复方；慢性创面愈合；PI3K/Akt信号通路；机制 |
| KEYWORDS： | TCM； active ingredients； couplet medicinals； compound formulas； chronic wound healing； PI3K/Akt signaling |
| 阅读数： | 10 次 |
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