返回 
加入收藏
环泊酚复合局麻用于老年患者痔疮切除术的效果及安全性研究
x
请在关注微信后，向客服人员索取文件
| 篇名： | 环泊酚复合局麻用于老年患者痔疮切除术的效果及安全性研究 |
| TITLE： | Study on the effect and safety of ciprofol combined with local anesthesia on elderly patients undergoing hemor-rhoidectomy |
| 摘要： | 目的 评Ш�蘎㤉㐑汓吃먵ⴓꀕ켵ㄫ*�㍋逜嬫뀚琜젉렐딆鐕匀。方法纳入2023年2月－2024年6月广西中医药大学附属瑞康医院肛肠科行痔疮切除术的老年患者108例，按计算机生成的随机序列将其分为依托咪酯组（54例）和环泊酚组（54例）；剔除术中出血、拒绝术后检查的患者各1例，最终有106例患者完成本试验（依托咪酯组52例、环泊酚组54例）。两组患者分别在依托咪酯0.2mg/kg或环泊酚0.3mg/kg+舒芬太尼0.1μg/kg辅助镇静联合局麻下行痔疮切除术。观察两组患者的镇静有效率，麻醉诱导时长，苏醒时长，手术时长，入室（T0）时、麻醉诱导成功（T1）时、手术开始10min（T2）时、苏醒（T3）时的血流动力学指标[心率（HR）、平均动脉压（MAP）、血氧饱和度（SpO2）、呼吸频率（RR）]，以及T0、T2、T3时的血清氧化应激指标[丙二醛（MDA）和超氧化物歧化酶（SOD）]水平，并记录不良反应发生情况。结果环泊酚组患者的麻醉诱导时长显著短于依托咪酯组（P＜0.05），苏醒时长显著长于依托咪酯组（P＜0.05）；两组患者T1、T2时的HR、MAP、RR均较同组T0时显著降低（P＜0.05），但组间各时间点各血流动力学指标比较，差异均无统计学意义（P＞0.05）；两组患者T2、T3时MDA水平均显著高于同组T0时，SOD水平则显著低于同组T0时，且环泊酚组显著优于同期依托咪酯组（P＜0.05）；环泊酚组术中发生体动的患者比例显著低于依托咪酯组（P＜0.05）。结论当环泊酚应用于老年患者痔疮切除术时，与依托咪酯相比，其在维持血流动力学稳定、抗氧化应激方面具有一定优势，且安全性较高。 |
| ABSTRACT： | OBJECTIVE To evaluate the effect and safety of ciprofol combined with local anesthesia on elderly patients undergoing hemorrhoidectomy. METHODS A total of 108 elderly patients who underwent hemorrhoidectomy at the Department of Proctology， Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from February 2023 to June 2024， were included. The patients were randomly divided into the etomidate group （54 cases） and the ciprofol group （54 cases） based on a computer-generated random sequence. One patient with intraoperative bleeding and one who refused postoperative examination were excluded， resulting in a final total of 106 patients completing this trial （52 in the etomidate group and 54 in the ciprofol group）. The two groups of patients underwent hemorrhoidectomy under local anesthesia with sedative assistance， receiving either etomidate at 0.2 mg/kg or ciprofol at 0.3 mg/kg combined with sufentanil at 0.1 μg/kg. The sedation success rate， induction time， recovery time， operation time and hemodynamic parameters [heart rate （HR）， mean arterial pressure （MAP）， pulse oxygen saturation （SpO2） and respiratory rate （RR）] were observed at baseline （T0）， after successful induction of anesthesia （T1）， 10 minutes after the start of surgery （T2）， and awakening （T3）. Additionally， the levels of oxidative stress markers [malondialdehyde （MDA） and superoxide dismutase （SOD）] were measured at T0， T2 and T3. The occurrence of adverse reactions was also recorded. RESULTS The induction time of the ciprofol group was significantly shorter than that of the etomidate group （P＜0.05）， while the recovery time was significantly longer in the ciprofol group compared to the etomidate group （P＜0.05）. AtT1 and T2， HR， MAP and RR of two groups were significantly lower compared to the same group at T0 （P＜0.05）. However， no significant differences were observed in the hemodynamic parameters at each time point between the two groups （P＞0.05）. At T2 and T3， the MDA levels in both groups were significantly higher than at T0， while the SOD levels were significantly lower than the same group at T0； the ciprofol group showed significantly better outcomes than the etomidate group at the same time points （P＜0.05）. The proportion of patients with intraoperative somatic movements was significantly lower in the ciprofol group compared to the etomidate group （P＜0.05）. CONCLUSIONS When ciprofol is used in elderly patients undergoing hemorrhoidectomy， it demonstrates certain advantages over etomidate in maintaining hemodynamic stability and reducing oxidative stress. Additionally， ciprofol has higher safety. |
| 期刊： | 2025年第36卷第08期 |
| 作者： | 冯嘉慧；邹和林；李福军 |
| AUTHORS： | FENG Jiahui，ZOU Helin，LI Fujun |
| 关键字： | 环泊酚；依托咪酯；痔疮切除术；氧化应激；老年患者 |
| KEYWORDS： | ciprofol； etomidate； hemorrhoidectomy； oxidative stress； elderly patients |
| 阅读数： | 5 次 |
| 本月下载数： | 0 次 |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！
