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肠内免疫微生态营养联合ω-3鱼油脂肪乳用于肝细胞癌切除术后的临床观察
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| 篇名： | 肠内免疫微生态营养联合ω-3鱼油脂肪乳用于肝细胞癌切除术后的临床观察 |
| TITLE： | Clinical observation of enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion for postoperative hepatocellular carcinoma resection |
| 摘要： | 目的 研究肠内免疫微生态营养联合ω-3鱼油脂肪乳对肝细胞癌切除患者术后恢复、免疫功能、肝功能及炎症水平的影响，以及用药的安全性。方法选取2020年6月－2023年12月我院收治的106例肝细胞癌患者，按随机数字表法分为对照组和研究组，每组各53例。所有患者行肝细胞癌切除术，术后对照组患者给予整蛋白型肠内营养液+强化肠内免疫微生态营养，研究组患者在对照组用药的基础上给予ω-3鱼油脂肪乳注射液。比较两组患者的临床指标（术后排气、排便、下床活动及住院时间）、肝功能指标[丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）、天冬氨酸转氨酶（AST）]、免疫功能指标（CD3+、CD4+、CD8+、CD4+/CD8+）、炎症因子指标[肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）、IL-6、IL-8]、肠黏膜屏障指标[D-乳酸、肠道脂肪酸结合蛋白（I-FABP）]，记录不良反应发生情况。结果研究组患者的术后排气时间、术后排便时间、住院时间均显著短于对照组，下床活动时间显著长于对照组（P＜0.05）。治疗后，两组患者的ALT、LDH、AST、CD8+、炎症因子、D-乳酸、I-FABP均显著低于同组治疗前，且研究组显著低于对照组（P＜0.05）；两组患者的CD4+、CD3+、CD4+/CD8+均显著高于同组治疗前，且研究组显著高于对照组（P＜0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论肠内免疫微生态营养联合ω-3鱼油脂肪乳能缩短肝细胞癌切除术后患者的康复时间，提高免疫功能，降低炎症反应，改善肝功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE To study the effects of enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion on postoperative recovery， immune function， liver function and inflammation level in patients with hepatocellular carcinoma resection， as well as the safety of the medication. METHODS A total of 106 patients with hepatocellular carcinoma admitted to our Hospital from June 2020 to December 2023 were selected and divided into control group and study group according to the random number table method， with 53 cases in each group. After undergoing hepatocellular carcinoma resection， control group was given Intacted protein enteral nutrition solution+Enhanced enteral immune microecological nutrition， and the study group was given ω-3 fish oil fat emulsion injection based on the control group. The clinical indicators （postoperative exhaust time， defecation time， postoperative ambulation， and hospital stay）， liver function indicators [alanine transaminase （ALT）， lactate dehydrogenase （LDH）， aspartate transaminase （AST）]， immune function indexes （CD3+ ， CD4+ ， CD8+ ， CD4+/CD8+）， inflammatory factor indexes [tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， IL-6， IL-8]， and indicators of intestinal mucosal barrier [D-lactic acid， intestinal fatty acid binding protein （I-FABP）] were compared between 2 groups， and the occurrence of ADR was recorded. RESULTS Compared with the control group， the postoperative exhaust time， postoperative defecation time， and hospital stay of the study group were shortened significantly， and postoperative ambulation increased significantly （P＜0.05）. After treatment， ALT， LDH， AST， CD8+， inflammatory factors， D-lactic acid and I-FABP of 2 groups were significantly lower than before treatment， and the study group was significantly lower than the control group （P＜0.05）； CD4+， CD3+， and CD4+/CD8+ of two groups were significantly higher than before treatment， and the study group was significantly higher than the control group （P＜0.05）. There was no significant difference in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS Enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion injection can shorten the recovery time of patients after hepatocellular carcinoma resection， improve immune function， reduce inflammatory response， and improve liver function with good safety. |
| 期刊： | 2025年第36卷第08期 |
| 作者： | 张明；颜华英；徐东平；王晶晶；张立成；齐玉梅 |
| AUTHORS： | ZHANG Ming，YAN Huaying，XU Dongping，WANG Jingjing，ZHANG Licheng，QI Yumei |
| 关键字： | 肠内免疫微生态营养；ω-3鱼油脂肪乳；肝细胞癌；免疫功能；炎症因子 |
| KEYWORDS： | enteral immune microecological nutrition； ω-3 fish oil fat emulsion； hepatocellular carcinoma； immune function； |
| 阅读数： | 2 次 |
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