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龙葵的保肝作用及机制研究进展
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| 篇名： | 龙葵的保肝作用及机制研究进展 |
| TITLE： | Research progress on hepatoprotective effect and mechanism of Solanum nigrum |
| 摘要： | 龙葵是一种广泛分布于我国的传统中草药，富含生物碱、皂苷等活性成分，在多种肝病治疗中展现出显著的保肝作用和多样的作用机制。龙葵可通过抗炎、抗氧化、调节肠道菌群、抑制纤维化等途径防治化学性肝损伤；可通过调节脂质代谢、抑制脂肪生成并促进脂肪分解来防治脂肪肝；可通过抗病毒作用防治病毒性肝炎；可通过诱导肿瘤细胞凋亡、阻滞细胞周期、抑制肿瘤细胞增殖与转移等多种机制防治肝癌。在临床上，龙葵已用于肝癌、慢性乙肝后肝纤维化的治疗，疗效较好且安全性较高。未来应不断深化对龙葵作用机制的研究，并推动其新药的开发和应用，以造福更多肝病患者。 |
| ABSTRACT： | Solanum nigrum is a traditional Chinese herb widely distributed in China. It is rich in active ingredients such as alkaloids and saponins， and has shown remarkable hepatoprotective effects and various mechanisms in the treatment of various liver diseases. It can prevent and treat chemical liver injury through anti-inflammatory， antioxidant， gut microbiota-regulating， and anti- fibrotic pathways. In the prevention and treatment of fatty liver disease， it can regulate lipid metabolism， inhibit lipogenesis， and promote fat degradation. It has potential antiviral activity against viral hepatitis. By inducing tumor cell apoptosis， arresting the cell cycle， and inhibiting tumor cell proliferation and metastasis and so on， it plays a role in the prevention and treatment of liver cancer. Clinically， S. nigrum has been used in the treatment of liver cancer and liver fibrosis after chronic hepatitis B， showing good efficacy and high safety. Future research should focus on further elucidating its mechanisms of action and promoting the development and application of new drugs， in order to benefit more patients with liver diseases. |
| 期刊： | 2025年第36卷第07期 |
| 作者： | 张月明；黄枫薇；翟婧卉；张四喜 |
| AUTHORS： | ZHANG Yueming，HUANG Fengwei，ZHAI Jinghui，ZHANG Sixi |
| 关键字： | 龙葵；保肝作用；作用机制；临床应用；肝癌；肝纤维化；化学性肝损伤；病毒性肝炎；脂肪肝 |
| KEYWORDS： | Solanum nigrum； hepatoprotective effects； mechanism of action； clinical application； liver cancer； liver fibrosis； |
| 阅读数： | 19 次 |
| 本月下载数： | 1 次 |
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