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食欲素及其受体相关药物对抑郁症影响的研究进展
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| 篇名： | 食欲素及其受体相关药物对抑郁症影响的研究进展 |
| TITLE： | Research advances in the effects of orexin and its receptor-related drugs on depression |
| 摘要： | 抑郁症是一种精神类障碍疾病，其主要症状包括情绪低落、兴趣减退、焦虑不安、睡眠障碍以及食欲改变等。食欲素是一种位于下丘脑神经元中的神经肽，广泛分布于整个中枢神经系统，参与多种抑郁行为相关生理过程的调节。本文综述了食欲素及其受体相关药物对抑郁症的影响，发现食欲素通过与相关受体结合对多脑区产生复杂的调节作用，影响情绪、睡眠、焦虑等；抑郁症患者血浆食欲素水平呈现异常的表达状态；外源性食欲素A、选择性食欲素受体1拮抗剂（SORA1s）、选择性食欲素受体2拮抗剂（SORA2s）、双重食欲素受体拮抗剂（DORAs）对多种抑郁症模型动物表现出抗抑郁作用。外源性食欲素A的临床试验相对较少；SORA1s、SORA2s相关药物（如JNJ-61393215、塞托雷生）在抑郁症的治疗中取得了显著进展；DORAs（如Suvorexant、Lembo‐rexant和Daridorexant）主要用于治疗失眠，其中Suvorexant在缓解焦虑和抑郁症状方面也显示出潜力。 |
| ABSTRACT： | Depression is a psychiatric disorder whose main symptoms include low mood， loss of interest， anxiety， sleep disturbances， and changes in appetite. Orexin， a neuropeptide located in hypothalamic neurons， has a wide range of projections throughout the central nervous system and is involved in various behavioral modulations related to depression. This study systematically reviewed the effects of orexin and its receptor-related drugs on depression and found that orexin could exert complex regulatory effects on multiple brain regions by binding to related receptors， affecting emotions， sleep， anxiety， etc. The abnormal state of expression of plasma orexin in patients with depression was found. Exogenous orexin-A， selective orexin receptor 1 antagonists （SORA1s）， selective orexin receptor 2 antagonists （SORA2s）， and dual orexin receptor antagonists （DORAs） have demonstrated antidepressant-like effects in various animal models of depression. Among them， clinical trials involving exogenous orexin-A are relatively scarce. Drugs related to SORA1s and SORA2s， such as JNJ-61393215 and Setorexant， have made significant progress in the treatment of depression. DORAs， such as Suvorexant， Lemborexant， and Daridorexant， are primarily used to treat insomnia. Notably， Suvorexant has also shown potential in alleviating symptoms of anxiety and depression. |
| 期刊： | 2025年第36卷第04期 |
| 作者： | 蒋召书；程茗；杨洁；曹峰；张震 |
| AUTHORS： | JIANG Zhaoshu，CHENG Ming，YANG Jie，CAO Feng，ZHANG Zhen |
| 关键字： | 食欲素；抑郁症；受体拮抗剂；临床研究 |
| KEYWORDS： | orexin； depression； receptor antagonists； clinical study |
| 阅读数： | 14 次 |
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