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山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识
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| 篇名： | 山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识 |
| TITLE： | Expert consensus on perioperative rational use and comprehensive clinical evaluation of NSAIDs in Shandong Province |
| 摘要： | 目的 为非甾体抗炎药（NSAIDs）在围手术期的合理使用提供依据，为医疗机构评价、遴选NSAIDs提供实践方法与技术参考。方法由青岛大学附属医院发起，山东省药师协会临床药学专业委员会、山东省医学会临床个体化用药检测与指导分会、山东省药师协会药品临床综合评价工作委员会、山东省医学会疼痛学分会等联合山东省内多家医疗机构，组织来自山东省内17家医院的22名药学和医学专家，基于循证医学证据，通过文献研究法、专家访谈法和问卷调查法，构建围手术期NSAIDs的合理用药和临床综合评价专家共识，并对山东省内临床常用的包括塞来昔布、依托考昔、艾瑞昔布、布洛芬在内的9个品种共计13个品规（含参比/原研及国家/山东省集中带量采购品种）药品进行临床综合评价。结果与结论本研究对围手术期术前预防性使用和术后使用NSAIDs以及使用禁忌、消化道风险、心血管系统风险、出血风险和肾损伤风险形成了共识意见，建立了包含安全性、有效性、经济性、创新性、适宜性、可及性6个维度的围手术期NSAIDs使用评价与遴选标准。临床综合评价结果显示，得分排名前6（均超过70分）的药品依次为塞来昔布胶囊（西乐葆）和塞来昔布胶囊（奈奇）、双氯芬酸钠缓释片、依托考昔片（安康信）和依托考昔片（齐明舒）、注射用帕瑞昔布钠。随着临床研究的进展，本共识将会进一步更新和调整；医疗机构可结合实践情况，制定适合本医疗机构的NSAIDs临床综合评价体系。 |
| ABSTRACT： | OBJECTIVE To provide a basis for the rational use of nonsteroidal anti-inflammatory drugs （NSAIDs） in the perioperative period， and provide practical methods and technical references for the evaluation and selection of NSAIDs in medical institutions. METHODS Initiated by the Affiliated Hospital of Qingdao University， Clinical Pharmacy Professional Committee of the Shandong Pharmacists Association， Clinical Individualised Drug Testing and Guidance Branch of the Shandong Medical Association， Comprehensive Clinical Medication Evaluation Working Committee of the Shandong Pharmacists Association， Pain Branch of the Shandong Medical Association in conjunction with several medical institutions in Shandong Province organized 22 pharmaceutical experts and medical experts from 17 hospitals in Shandong Province to form a consensus on the rational use and comprehensive clinical evaluation of NSAIDs in the perioperative period through the literature research method， expert interview method and questionnaire survey method based on evidence-based medicine. A comprehensive clinical evaluation was also conducted on a total of 13 specifications of 9 commonly used clinical drug varieties in Shandong Province， including celecoxib， etoricoxib， imrecoxib， ibuprofen （containing reference/original drugs and national/Shandong Province’s centralized volume-based procurement varieties）. RESULTS & CONCLUSIONS A consensus opinion was formed on preoperative prophylactic use and postoperative use of NSAIDs， as well as contraindications， digestive tract risk， cardiovascular system risk， bleeding risk and kidney injury risk in the perioperative period. The evaluation and selection criteria of perioperative use of NSAIDs were established， involving 6 dimensions of safety， efficacy， economy， innovation， appropriateness， and accessibility. The results of comprehensive clinical evaluation showed that the top 6 drugs （scores over 70） were Celecoxib capsules （Celebrex） and Celecoxib capsules （Naiqi）， Diclofenac sodium sustained-release tablets，Etocoxib tablets （Arcoxia） and Etocoxib tablets （Qimingshu）， and Parecoxib sodium for injection. With the progress of clinical research， this consensus will be further updated and adjusted， and medical institutions can combine with the practice to develop a comprehensive clinical evaluation system of NSAIDs suitable for their institutions. |
| 期刊： | 2025年第36卷第04期 |
| 作者： | 山东省药师协会临床药学专业委员会；山东省医学会临床个体化用药检测与指导分会；山东省药师协会药品临床综合评价工作委员会；山东省医学会疼痛学分会；《山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识》制定组 |
| AUTHORS： | Clinical Pharmacy Professional Committee of the Shandong Pharmacists Association，Clinical Individualised Drug Testing and Guidance Branch of the Shandong Medical Association，Comprehensive Clinical Medication Evaluation Working Committee of the Shandong |
| 关键字： | 非甾体抗炎药；围手术期；合理用药；临床综合评价；专家共识 |
| KEYWORDS： | nonsteroidal anti-inflammatory drugs； perioperative； rational drug use； comprehensive clinical evaluation； expert |
| 阅读数： | 5 次 |
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