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倍半萜类化合物抗肝癌作用机制研究进展
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| 篇名： | 倍半萜类化合物抗肝癌作用机制研究进展 |
| TITLE： | Research progress on the mechanism of sesquiterpenoids against hepatocellular carcinoma |
| 摘要： | 肝癌作为世界上较为常见的实体器官恶性肿瘤之一，其在我国的发病率已攀升至第4位，病死率居第2位，严重威胁着人民的健康。萜类化合物是自然界中广泛存在的天然活性物质，其中倍半萜类化合物数量众多，它们展现出多种药理活性，如抗肿瘤、抗菌、抗炎、抗病毒及抗氧化等。本文对倍半萜类化合物2015－2024年抗肝癌作用机制研究进展进行综述。结果显示，近10年文献报道了24种用于治疗肝癌的倍半萜类化合物，这些化合物通过抑制癌细胞增殖、诱导凋亡、阻止侵袭转移、调节免疫及增强抗耐药性等途径展现出治疗肝癌的潜力。这些机制主要涉及三大调控路径：磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路、核因子κB信号通路、线粒体途径。未来，需继续探索新的有较高研究价值的抗肝癌药物，深入分析多成分、多靶点、多途径协同抗肝癌的作用机制，并加速成品研发，以期在临床中广泛应用。 |
| ABSTRACT： | As one of the most common solid organ malignant tumors in the world， hepatocellular carcinoma has climbed to the fourth place in incidence rate and the second place in mortality in China， which seriously threatens people’s health. Terpenoids are natural active substances widely present in nature， among which sesquiterpenoids are numerous. They exhibit a variety of pharmacological activities， such as anti-tumor， antibacterial， anti-inflammatory， antiviral and antioxidant activities. This article reviews the research progress on the anti-hepatocellular carcinoma mechanism of sesquiterpenes from 2015 to 2024. The results showed that 24 sesquiterpenoids for the treatment of hepatocellular carcinoma have been reported in the literature in the past 10 years， and these compounds have shown potential in treating hepatocellular carcinoma by inhibiting cancer cell proliferation， inducing apoptosis， preventing invasion and metastasis， regulating immunity， and enhancing anti-drug resistance. The mechanism of anti-hepatocellular carcinoma mainly involves three regulatory pathways: phosphatidylinositol 3-kinase/protein kinase B/ mammalian target of rapamycin signaling pathway， nuclear factor kappa-B signaling pathway， and mitochondrial pathway. In the future， it is necessary to continue to explore new anti-hepatocellular carcinoma drugs with high research value， conduct in-depth analysis on the mechanism of synergistic anti-hepatocellular cancer effects of multiple components， targets， pathways， and accelerate the development of finished products in order to be widely used in clinical practice. |
| 期刊： | 2025年第36卷第03期 |
| 作者： | 毛景欣；杜鑫；李艳 |
| AUTHORS： | MAO Jingxin，DU Xin，LI Yan |
| 关键字： | 倍半萜类化合物；肝癌；药理作用；作用机制 |
| KEYWORDS： | sesquiterpenoids； hepatocellular carcinoma； pharmacological action； mechanism |
| 阅读数： | 11 次 |
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