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早期预测多黏菌素相关急性肾损伤的新型生物标志物研究进展
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| 篇名： | 早期预测多黏菌素相关急性肾损伤的新型生物标志物研究进展 |
| TITLE： | Study progress of novel biomarkers for early prediction of polymyxin-associated acute kidney injury |
| 摘要： | 多黏菌素是治疗多重耐药革兰氏阴性菌感染的关键药物，但其显著的肾毒性严重限制了临床应用。为提升其安全性并改善患者预后，探索早期预测多黏菌素相关急性肾损伤的新型生物标志物尤为重要。胱抑素C、肾损伤分子1、中性粒细胞明胶酶相关脂质运载蛋白、N-乙酰-β-葡萄糖苷酶、β2微球蛋白等新型生物标志物在多黏菌素相关急性肾损伤早期预测中表现出了明显的优势。相较于传统标志物，这些标志物可在肾损伤的早期阶段提供敏感、特异的诊断信息，有助于优化个体治疗方案，降低临床风险。然而，检测成本较高、操作复杂等问题仍限制了上述标志物的临床推广。未来的研究应重点优化新型生物标志物的检测技术，简化操作流程并降低成本，同时开展多中心、大样本的随机对照试验，系统评估各种新型生物标志物的敏感性和特异性，以推动其在临床肾损伤预测领域中的应用。 |
| ABSTRACT： | Polymyxin is an essential antibiotic for treating multidrug-resistant Gram-negative bacterial infections； however， its significant nephrotoxicity greatly limits its clinical application. To enhance its safety and improve patient outcomes， the study of novel biomarkers for the early prediction of polymyxin-associated acute kidney injury is critically important. Novel biomarkers， such as cystatin C， kidney injury molecule-1， neutrophil gelatinase-associated lipocalin， N-acetyl-β-glucosaminidase， β2- microglobulin， have shown obvious advantages in the early prediction of polymyxin-associated acute kidney injury. Compared to traditional biomarkers， these biomarkers can provide sensitive and specific diagnostic information in the early stages of kidney injury， helping to optimize individualized treatment plans and reduce clinical risks. However， the high cost of detection and complex operation still limit their clinical promotion. Future research should focus on optimizing the detection technology of new biomarkers， simplifying the operation process and reducing costs， while conducting multi-center， large-scale randomized controlled trials to systematically evaluate the sensitivity and specificity of various novel biomarkers， in order to promote their application in the field of prediction of renal injury in clinical practice. |
| 期刊： | 2025年第36卷第02期 |
| 作者： | 杨戈；杨君；刘芳；陈勇川；张洪 |
| AUTHORS： | YANG Ge，YANG Jun，LIU Fang，CHEN Yongchuan，ZHANG Hong |
| 关键字： | 新型生物标志物；多黏菌素；急性肾损伤；肾毒性；早期预测 |
| KEYWORDS： | novel biomarkers； polymyxin； acute kidney injury； nephrotoxicity； early prediction |
| 阅读数： | 16 次 |
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