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基因多态性对侵袭性真菌感染患者伏立康唑血药浓度影响的Meta分析
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| 篇名： | 基因多态性对侵袭性真菌感染患者伏立康唑血药浓度影响的Meta分析 |
| TITLE： | Meta-analysis of the effects of gene polymorphism on plasma concentration of voriconazole in patients with invasive fungal infection |
| 摘要： | 目的 评价基因多态性对侵袭性真菌感染患者伏立康唑（VRZ）血药谷浓度（cmin）的影响。方法检索theCochraneLibrary、Embase、PubMed、WebofScience、中国生物医学文献数据库、中国知网、维普网和万方数据，收集基因多态性与VRZcmin相关的文献，检索时间为建库至2024年4月。筛选文献，提取资料，评价文献质量后，使用R4.3.2软件进行Meta分析。结果共纳入21篇文献，共计2454例患者。Meta分析结果显示，CYP2C19IM型、PM型患者的VRZcmin均显著高于EM型，而IM型显著低于PM型（P＜0.01）；CYP2C9rs1057910AA型患者的VRZcmin显著高于AC/CC型，CYP3A5rs776746CC型患者的VRZcmin显著高于TT型（P＜0.01）；PORrs10954732GG型患者的VRZcmin显著高于GA型和AA型，PORrs1057868CT型患者的VRZcmin显著低于TT型（P＜0.01）；ABCB1rs1045642CC型患者的VRZcmin显著高于TT型（P＜0.05）；NR1I2rs2472677CT型患者的VRZcmin显著高于TT型，NR1I2rs7643645AA型患者的VRZcmin显著高于AG型（P＜0.05）；ABCC2rs717620CC型患者的VRZcmin均显著低于CT型和TT型，且CT型显著低于TT型（P＜0.01）。结论CYP2C19、CYP2C9rs1057910、CYP3A5rs776746、PORrs10954732、ABCB1rs1045642、NR1I2rs7643645突变等位基因均可导致VRZ血药浓度降低，ABCC2rs717620突变等位基因则可导致VRZ血药浓度升高。 |
| ABSTRACT： | OBJECTIVE To evaluate the influence of gene polymorphism on plasma minimum concentration （cmin） of voriconazole （VRZ） in patients with invasive fungal infection. METHODS The Cochrane Library， Embase， PubMed， Web of Science， China Biomedical Literature Database， CNKI， VIP and Wanfang Data were searched for literature on the correlation between gene polymorphisms and cmin of VRZ from inception to April 2024. After screening the literature， extracting data， and evaluating the quality of the literature， meta-analysis was performed using R 4.3.2 software. RESULTS A total of 21 studies with 2 454 patients were included. The results of meta-analysis showed that the VRZ cmin of CYP2C19 IM and PM types was significantly higher than EM type， and the VRZ cmin of IM type was significantly lower than PM type （P＜0.01）. The VRZ cmin of CYP2C9 rs1057910 AA type was significantly higher than AC/CC type， and that of CYP3A5 rs776746 CC type was significantly higher than TT type （P＜0.01）. The VRZ cmin of POR rs10954732 GG type was significantly higher than GA and AA types， and that of POR rs1057868 CT type was significantly lower than TT type （P＜0.01）. The VRZ cmin of ABCB1 rs1045642 CC type was significantly higher than TT type （P＜0.05）. The VRZ cmin of NR1I2 rs2472677 CT type was significantly higher than TT type， and rs7643645 AA type was significantly higher than AG type （P＜0.05）. The VRZ cmin of ABCC2 rs717620 CC type was significantly lower than CT type and TT type， and the CT type was significantly lower than TT type （P＜0.01）. CONCLUSIONS Mutant alleles in CYP2C19， CYP2C9 rs1057910， CYP3A5 rs776746， POR rs10954732， ABCB1 rs1045642 and NR1I2 rs7643645 can lead to a decrease in VRZ plasma concentration， and mutant allele in ABCC2 rs717620 can lead to an increase in VRZ plasma concentration. |
| 期刊： | 2025年第36卷第02期 |
| 作者： | 李雅暄；李兴德；王国徽；毛盼盼；马雪娇；宋沧桑 |
| AUTHORS： | LI Yaxuan，LI Xingde，WANG Guohui，MAO Panpan，MA Xuejiao，SONG Cangsang |
| 关键字： | 伏立康唑；侵袭性真菌感染；基因多态性；血药浓度；Meta分析 |
| KEYWORDS： | voriconazole； invasive fungal infection； gene |
| 阅读数： | 7 次 |
| 本月下载数： | 0 次 |
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