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利多卡因致心脏毒性的文献分析
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| 篇名： | 利多卡因致心脏毒性的文献分析 |
| TITLE： | Literature analysis of cardiotoxicity caused by lidocaine |
| 摘要： | 目的 探讨利多卡因致心脏毒性的临床特征，为临床安全用药提供参考。方法以“利多卡因”“心脏毒性”“lidocaine”“cardiotoxicity”等为中英文检索词，检索中国知网、万方数据、维普网、PubMed和Embase，收集利多卡因致心脏毒性相关文献并进行描述性分析。结果共纳入31篇文献，共计40例患者。40例患者中，男性23例、女性17例；年龄5个月～73岁，包括≤18岁患者4例、19～59岁17例、≥60岁19例。用药指征以手术麻醉为主（26例），给药途径以静脉给药、神经阻滞麻醉、局部浸润麻醉为主（15、6、6例）；34例患者的用药剂量均符合药品说明书规定；心脏毒性发生时间以用药后1min～1h最多（19例），主要症状为心动过缓、心房传导速度减慢、房室传导阻滞、窦性停搏等。34例患者经抢救和对症治疗后好转，6例患者死亡。结论利多卡因致心脏毒性可发生在各年龄段，以用药后1h内为主，主要表现为心律失常、心跳过快或过慢、房室传导阻滞等，且病情严重。临床在使用该药时，应加强对用药剂量、给药途径、毒性反应等的药学监护；出现相关症状时，应及时停药并进行对症治疗，以保障患者的用药安全。 |
| ABSTRACT： | OBJECTIVE To explore the clinical characteristics of cardiotoxicity caused by lidocaine， and provide a reference for the safe use of drug in clinical practice. METHODS Chinese and English search terms， such as “lidocaine”“ cardiotoxicity”， were used to search for literature related to lidocaine-induced cardiac toxicity from CNKI， Wanfang Data， VIP， PubMed and Embase， and conduct descriptive analysis. RESULTS A total of 31 papers were included， with 40 patients. Of the 40 patients， 23 were male and 17 were female； ages ranged from 5 months to 73 years， with 4 patients≤18 years old， 17 patients 19-59 years old， and 19 patients≥60 years old. The main indications for medication were surgical anesthesia （26 cases）， and the main routes of administration were intravenous administration， nerve block anesthesia and local infiltration anesthesia （15， 6， 6 cases）； the dosage of medication for 34 patients complied with the instructions； the most of cardiotoxicity occurred 1 min-1 h after medication （19 cases）， and the main symptoms were bradycardia， atrial conduction slowing， atrioventricular block， sinus arrest， etc. Thirty- four patients improved after resuscitation and symptomatic treatment， and six patients died. CONCLUSIONS Lidocaine-induced cardiotoxicity can occur in all ages， mainly within 1 h after administration， and is manifested as arrhythmia， tachycardia or tachycardia， atrioventricular block， etc.， which is severe. When using it clinically， it is necessary to strengthen pharmaceutical monitoring of medication dosage， administration route， toxic reactions， etc.； when relevant symptoms appear， medication should be stopped promptly and symptomatic treatment should be carried out， to protect the safety of drug use. |
| 期刊： | 2025年第36卷第02期 |
| 作者： | 姑丽尼格尔·艾尼瓦尔；程明霞；谢菡 |
| AUTHORS： | Gulinigeer·Ainiwaer，CHENG Mingxia，XIE Han |
| 关键字： | 利多卡因；心脏毒性；麻醉药；用药安全；文献分析 |
| KEYWORDS： | lidocaine； cardiotoxicity； anesthetic； safety of drug use； literature analysis |
| 阅读数： | 7 次 |
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