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儿童他克莫司个体化给药模型的研究进展
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| 篇名： | 儿童他克莫司个体化给药模型的研究进展 |
| TITLE： | Advances in individualized dosing models of tacrolimus for children |
| 摘要： | 他克莫司是儿童实体器官移植后预防免疫排斥反应的关键治疗药物，由于其治疗窗窄、个体间变异大，往往需要个体化用药物。近年来，随着治疗药物监测技术的推广，基于他克莫司血药浓度的个体化治疗模型发展迅猛。本文综述了近十年来国内外儿童他克莫司个体化给药模型的研究进展，包括基于群体药动学、生理药动学、机器学习和多元线性回归的剂量模拟方法，分析并概括了各模型的特点以及在儿童个体化给药中的应用情况，并介绍了他克莫司个体化给药辅助决策系统的发展现状。 |
| ABSTRACT： | Tacrolimus is a crucial therapeutic drug for preventing immune rejection after solid organ transplantation in children. Due to the narrow treatment window and significant individual variability， personalized treatment is often required. In recent years， with the promotion of therapeutic drug monitoring technology， individualized treatment models based on tacrolimus drug concentration have developed rapidly. This article reviews the research progress of individualized dosing models for tacrolimus in children both domestically and internationally over the past decade. It includes dose simulation methods based on population pharmacokinetics， physiologically based pharmacokinetics， machine learning， and multiple linear regression. The characteristics of each model and its application in pediatric individualized dosing are analyzed and summarized. Additionally， the current development status of decision support systems for individualized tacrolimus dosing is introduced. |
| 期刊： | 2025年第36卷第01期 |
| 作者： | 沈黎；李智平 |
| AUTHORS： | SHEN Li，LI Zhiping |
| 关键字： | 他克莫司；个体化给药；给药模型；儿童；器官移植；药动学 |
| KEYWORDS： | tacrolimus； individualized dosing； dosing model； children； organ transplantation； pharmacokinetics |
| 阅读数： | 14 次 |
| 本月下载数： | 1 次 |
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