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老年肌少症患者接受参苓白术散联合营养支持和运动干预的临床评价
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| 篇名： | 老年肌少症患者接受参苓白术散联合营养支持和运动干预的临床评价 |
| TITLE： | Clinical evaluation of elderly patients with sarcopenia receiving Shenling baizhu powder combined with nutrition and exercise intervention |
| 摘要： | 目的 探讨老年肌少症患者接受参苓白术散联合营养支持和运动干预的安全性、有效性和经济性，为临床合理用药提供参考。方法将237例老年肌少症患者随机分为观察组（118例）和对照组（119例）。2组患者均给予营养支持和运动干预；观察组患者在此基础上加用参苓白术散，每次6g，每天3次；3个月后比较2种方案的安全性、有效性和经济性。结果2组患者均顺利完成随访。干预前，2组患者的骨骼肌质量指数（SMI）、握力和6m步速比较，差异均无统计学意义（P＞0.05）。干预后，观察组患者的握力显著大于对照组（25.05kgvs.23.18kg，P＜0.01）；肌少症治疗有效率、SMI和6m步速虽高于或大于对照组，但差异均无统计学意义（P＞0.05）。观察组患者的不良反应/事件发生率虽低于对照组（14.41%vs.16.81%），但差异无统计学意义（P＝0.611）。与对照组方案相比，观察组方案的成本较高（981.25元vs.913.94元）、效果较好（有效率0.6186vs.0.5630），增量-成本效果比为1210.61元。敏感性分析结果与成本-效果分析结果一致。结论老年肌少症患者接受参苓白术散联合营养支持和运动干预后，可显著增强握力，且不会提高不良反应/事件的发生率；与对照组方案相比较，观察组每增加1例肌少症治疗有效患者需多花费1210.61元。 |
| ABSTRACT： | OBJECTIVE To explore the safety， effectiveness， and cost-effectiveness of elderly patients with sarcopenia receiving Shenling baizhu powder combined with nutrition and exercise intervention， providing a reference for rational clinical drug use. METHODS A total of 237 elderly sarcopenia patients were randomly assigned to an observation group （118 cases） and a control group （119 cases）. Both groups of patients received nutrition and exercise intervention； the observation group added Shenling baizhu powder （6 g each time， three times daily） on this basis. The safety， effectiveness， and cost-effectiveness of the two plans were compared after 3 months. RESULTS Both groups of patients completed the follow-up. Before intervention， no significant difference was observed in skeletal muscle index （SMI）， grip strength， and 6-minute walk test （6MWT） speed between the two groups （P＞0.05）. After intervention， the grip strength of the patients in the observation group was significantly greater than that of the control group （25.05 kg vs. 23.18 kg， P＜0.01）； the treatment response rate of sarcopenia， SMI， and 6MWT speed were higher than those of the control group， butthe differences were not statistically significant （P＞0.05）. The adverse reaction/event rate of the patients in the observation group was lower than that of the control group （14.41% vs. 16.81%， P＝0.611）， but the difference was not statistically significant. Compared with the control group’s plan， the cost of the observation group’s plan was higher （981.25 yuan vs. 913.94 yuan）， and the effect was better （effectiveness rate： 0.618 6 vs. 0.563 0）， with an incremental cost-effectiveness ratio of 1 210.61 yuan. The results of the sensitivity analysis were consistent with the cost-effectiveness analysis results. CONCLUSION Elderly patients with sarcopenia who receive Shenling baizhu powder combined with nutrition and exercise intervention can significantly strengthen grip strength without increasing the incidence of adverse reactions/events. Compared with the control group plan， the observation group needs to spend an additional 1 210.61 yuan for each additional effective patient with sarcopenia. |
| 期刊： | 2024年第35卷第21期 |
| 作者： | 蒋欢欢；陈冬；付爱双；戈艳蕾；王强；李世滋；申慧琴；李霞；王颖聪；陈云飞 |
| AUTHORS： | JIANG Huanhuan，CHEN Dong， FU Aishuang，GE Yanlei，WANG Qiang，LI Shizi，SHEN Huiqin，LI Xia，WANG Yingcong，CHEN Yunfei |
| 关键字： | 参苓白术散；老年；肌少症；营养支持；运动干预；成本-效果分析 |
| KEYWORDS： | Shenling baizhu powder； elderly； sarcopenia； nutrition support； exercise intervention； cost-effectiveness analysis |
| 阅读数： | 5 次 |
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