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中药活性成分防治老年性黄斑变性的作用及其新型眼部递送制剂研究进展
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| 篇名： | 中药活性成分防治老年性黄斑变性的作用及其新型眼部递送制剂研究进展 |
| TITLE： | Effects of active ingredients of traditional Chinese medicine in the prevention and treatment of senile macular degeneration and the research progress of its ocular new drug delivery preparations |
| 摘要： | 老年性黄斑变性（SMD）是一种造成老年人视力损伤的眼部黄斑区退行性疾病，发病率较高，是目前国内外眼科疾病治疗研究的重点和难点。本文对防治SMD的常用中药活性成分及其新型眼部递送制剂进行综述，结果显示，许多中药活性成分可通过抗氧化、抗衰老、抗凋亡、抗炎等多种途径抑制SMD的病情进展。但由于大多数中药活性成分具有溶解度低、化学性质不稳定以及难以克服眼部屏障等缺点，严重阻碍了其在治疗SMD中的临床应用。以脂质体、固体脂质纳米粒、微乳/纳米乳、原位凝胶等为代表的新型制剂在眼部药物递送方面具有良好的应用前景。 |
| ABSTRACT： | Senile macular degeneration（SMD） is a degenerative disease of the macular region of the eye that causes visual impairment in older people worldwide. It is the focus and difficulty of the treatment of ophthalmic diseases at home and abroad. This paper reviewed traditional Chinese medicine （TCM） active ingredients for the treatment and prevention of SMD， and its new ocular delivery preparations. Studies have shown that many active ingredients of TCM can inhibit the progression of SMD through various ways such as anti-oxidation， solid lipid nanoparticles， microemulsions/nanoemulsions， in-situ gel， etc. However， due to the low solubility， chemical instability and difficulty in overcoming the eye barrier of most TCM active ingredients， their clinical application in the treatment of SMD is seriously hindered. New preparations， such as liposomes， solid lipid nanoparticles， microemulsion/nanoemulsion， in situ gels， have good application prospects in ocular drug delivery. |
| 期刊： | 2024年第35卷第19期 |
| 作者： | 朱雅迪；李维；李淑瑶；李寒梅；邹亮 |
| AUTHORS： | ZHU Yadi，LI Wei，LI Shuyao，LI Hanmei，ZOU Liang |
| 关键字： | 老年性黄斑变性；中药活性成分；氧化应激；炎症；纳米制剂 |
| KEYWORDS： | senile macular degeneration； active ingredients of traditional Chinese medicine； oxidative stress； inflammation； |
| 阅读数： | 11 次 |
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