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中药活性成分及复方调控JAK/STAT信号通路改善肝纤维化的研究进展
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| 篇名： | 中药活性成分及复方调控JAK/STAT信号通路改善肝纤维化的研究进展 |
| TITLE： | Research progress of active components and compounds of traditional Chinese medicine improving liver fibrosis by regulating JAK/STAT signaling pathway |
| 摘要： | 肝纤维化是各种慢性肝损伤的病理过程，若不及时治疗，最终可能导致肝硬化或肝癌。Janus激酶/信号转导及转录激活蛋白（JAK/STAT）信号通路与肝纤维化的发生发展密切相关。本文基于JAK/STAT信号通路总结了中药活性成分及复方改善肝纤维化的研究进展，发现活血化瘀类（如鬼箭羽醇、紫杉醇等成分及二十五味松石丸、肝复康等复方）、清热解毒类（如桦木酸、杠板归总黄酮等成分及片仔癀、克癀胶囊等复方）、疏肝行气类（如秦皮素、葫芦素B等成分及柴胡疏肝散、小柴胡汤等复方）中药活性成分和复方均可通过抑制JAK/STAT信号通路活性，降低炎症反应，抑制肝星状细胞增殖等，发挥改善肝纤维化的作用。 |
| ABSTRACT： | Hepatic fibrosis is a pathological process of chronic liver injury. Without timely intervention and treatment， liver fibrosis may eventually lead to liver cirrhosis and cancer. Janus kinase （JAK）/signal transducer and activator of transcription （STAT） signaling pathway is closely associated with the occurrence and development of liver fibrosis. Based on this， this paper summarized and analyzed the mechanism and effects of active ingredients and compounds of traditional Chinese medicine improving liver fibrosis based on JAK/STAT signaling pathway. It is found that the active ingredients and compounds of traditional Chinese medicine that promote blood circulation and remove blood stasis （ingredients such as ethanol extract of Euonymus alatus and paclitaxel， as well as compounds such as Ershiwuwei songshi pill and Ganfukang）， clear away heat and toxic material （ingredients such as betulinic acid， total flavonoids from Persicaria perfoliata， as well as compounds such as Pianzaihuang and Kehuang capsules）， and sooth the liver and promote qi circulation （ingredients such as fraxetin and cucurbitacin B， as well as compounds such as Chaihu shugan powder and Xiaochaihu decoction） can all relieve liver fibrosis by inhibiting the activity of the JAK/STAT signaling pathway， reducing inflammatory reactions， and inhibiting the proliferation of hepatic stellate cells. |
| 期刊： | 2024年第35卷第15期 |
| 作者： | 邓斯铭；刘礼剑；黎丽群；杨成宁；韦金秀；李建锋；黄明珠；谢丽丽 |
| AUTHORS： | DENG Siming，LIU Lijian，LI Liqun，YANG Chengning，WEI Jinxiu，LI Jianfeng，HUANG Mingzhu，XIE Lili |
| 关键字： | 肝纤维化；JAK/STAT信号通路；中药；活性成分；复方 |
| KEYWORDS： | liver fibrosis； JAK/STAT signaling pathway； traditional Chinese medicine； active ingredients； compounds |
| 阅读数： | 26 次 |
| 本月下载数： | 0 次 |
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