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静脉用药复溶剂生成系统及溶媒配伍禁忌规则库的建立及应用
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| 篇名： | 静脉用药复溶剂生成系统及溶媒配伍禁忌规则库的建立及应用 |
| TITLE： | Establishment and application of intravenous drug resolvent generation system and solvent incompatibility rules library |
| 摘要： | 目的 规范注射用无菌粉末复溶剂及静脉用药溶媒的使用，保障临床用药安全。方法我院审方药师团队通过制定需用灭菌注射用水溶解的药品目录和静脉用药溶媒配伍禁忌表，在医院信息系统中搭建静脉用药复溶剂生成系统及静脉用药溶媒配伍禁忌规则库。统计分析我院2023年1－4月（静脉用药溶媒配伍禁忌规则库实施前）和2023年5－8月（实施后）审核干预的不合理医嘱，比较实施前后我院溶媒选择不合理医嘱数量、拦截率及药师对溶媒选择不合理医嘱干预成功率的变化情况。结果我院静脉用药溶媒配伍禁忌规则库实施前，共发现溶媒选择不合理医嘱5229组，其中严重不合理医嘱有1204组，拦截率为23.03%，审方药师对其的干预成功率为15.90%；实施后，共发现溶媒选择不合理医嘱3258组，其中严重不合理医嘱有1148组，拦截率为35.24%，药师对其的干预成功率为24.83%，均显著高于实施前（P＜0.01或P＜0.001）。结论我院通过建立并应用静脉用药复溶剂生成系统及静脉用药溶媒配伍禁忌规则库，显著提高了对溶媒选择不合理医嘱的拦截率和药师干预成功率，有助于保障患者用药安全。 |
| ABSTRACT： | OBJECTIVE To standardize the use of sterile powder for injection redissolution solvent and intravenous drugs diluent solvent， and ensure the safety of clinical drug use. METHODS The intravenous drug resolvent generation system and the intravenous drug solvent incompatibility rules library were constructed and operated by prescription-checking pharmacist team in our hospital by formulating a list of intravenous drugs needed to be dissolved with sterilized water for injection and a contraindication list of intravenous solvent compatibility. The unreasonable medical orders reviewed and intervened in our hospital from January to April 2023 （before the implementation of the intravenous drug solvent incompatibility rules library） and from May to August 2023 （after the implementation） were analyzed statistically to compare the number of unreasonable solvent selection orders， interception rate， and the success rate of pharmacists’ interventions for unreasonable solvent selection orders before and after the implementation. RESULTS Before the implementation of the solvent incompatibility rules library， a total of 5 229 groups of medical orders with unreasonable solvent selection in our hospital were identified， among which there were 1 204 groups of seriously unreasonable medical orders， with interception rate of 23.03% and the success rate of pharmacists’ intervention of 15.90%. After the implementation of the solvent incompatibility rules library， the total number of medical orders with unreasonable solvent selection was 3 258 groups， among which there were 1 148 groups of seriously unreasonable medical orders， with interception rate of 35.24% and success rate of pharmacists’ intervention of 24.83%， being significantly higher than before implementation （P＜0.01 or P＜0.001）. CONCLUSIONS The establishment and application of the intravenous drug resolvent generation system and the solvent incompatibility rules library can significantly increase the interception rate of unreasonable solvent selection orders and the success rate of pharmacists’ interventions, and ensure the safety of clinical drug use. |
| 期刊： | 2024年第35卷第14期 |
| 作者： | 黄莺；李培芳；杜德才；方明；刘圣 |
| AUTHORS： | HUANG Ying，LI Peifang，DU Decai，FANG Ming，LIU Sheng |
| 关键字： | 注射用无菌粉末；复溶剂；溶媒；配伍禁忌 |
| KEYWORDS： | sterile powder for injection； redissolution solvent； solvent； incompatibility |
| 阅读数： | 27 次 |
| 本月下载数： | 0 次 |
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