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曲安奈德给药途径及相应剂型的研究进展
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| 篇名： | 曲安奈德给药途径及相应剂型的研究进展 |
| TITLE： | Research progress in the route of administration and corresponding dosage form of triamcinolone acetonide |
| 摘要： | 曲安奈德作为一种临床应用广泛的糖皮质激素药物，可以通过眼部、鼻腔、关节腔、皮肤等多途径给药，用于治疗关节炎、黄斑水肿、鼻炎、荨麻疹等多种局部疾病。曲安奈德作为一种在水中溶解度极低的药物，剂型与给药途径、给药部位息息相关。曲安奈德经注射（包括关节腔注射、玻璃体注射、脉络膜上腔注射、肌内注射）给药的剂型主要为混悬剂，代表性药物包括Kenalog-40®、Zilretta®、Triesence®、Xipere®等；鼻腔黏膜给药的剂型多为喷雾剂，代表性药物为Nasacort®；口腔黏膜给药的剂型多为贴剂、软膏剂和乳膏剂，代表性药物为Oracort®；经皮给药的剂型多为软膏剂、乳膏剂和洗剂，代表性药物包括Trianex®、Teva-Triacomb®等。现阶段有关曲安奈德各种给药途径的剂型研究主要围绕递送载体的构建、增加助溶剂或借助新型递送工具等展开。 |
| ABSTRACT： | As a glucocorticoid drug with wide clinical application， triamcinolone acetonide can be administered by multiple routes， such as eye， nose， joint cavity， and skin， for the treatment of various local diseases such as arthritis， macular edema， rhinitis， and urticaria. As a drug with extremely low solubility in water， the dose form of triamcinolone acetonide is closely correlated with administration route and site. The dosage form of triamcinolone acetonide administered via injection（including joint cavity injection， vitreous injection， suprachoroidal injection， intramuscular injection） is mainly suspension， and the representative drugs include Kenalog-40®， Zilretta®， Triesence®， Xipere®， etc.； the dosage forms of nasal mucosal administration are mostly sprays， and the representative drug is Nasacort®； the dosage forms of oral mucosal administration are mostly patches， ointments and creams， and the representative drug is Oracort®； the dosage forms for transdermal administration are mostly ointments， creams and lotions， and the representative drugs include Trianex®， Teva-Triacomb®， etc. At present， the research on dosage forms of triamcinolone acetonide by various administration routes mainly focuses on the construction of delivery carriers， the addition of cosolvents or the use of new delivery tools. |
| 期刊： | 2024年第35卷第07期 |
| 作者： | 邵天娇；金莉莉；王珊；闫博华；胡昕明；高静 |
| AUTHORS： | SHAO Tianjiao，JIN Lili，WANG Shan，YAN Bohua，HU Xinming，GAO Jing |
| 关键字： | 曲安奈德；给药途径；剂型；注射给药；黏膜给药；经皮给药 |
| KEYWORDS： | triamcinolone acetonide； route of administration； dosage form； injection administration； mucosal administration； |
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