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1例艾沙康唑致患者全血细胞减少的病例分析
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| 篇名： | 1例艾沙康唑致患者全血细胞减少的病例分析 |
| TITLE： | Case analysis of a patient with isavuconazonium-caused pancytopenia |
| 摘要： | 目的 正确识别和应对艾沙康唑引起的全血细胞减少的不良反应，为该药的安全使用提供参考。方法临床药师通过参与1例严重感染合并肾功能不全的患者使用艾沙康唑后出现全血细胞减少的病例分析，筛查患者住院期间所用药物，并结合药物的半衰期和相关文献，评估了该不良反应与艾沙康唑的关系及可能的发生机制。结果与结论患者全血细胞减少与艾沙康唑的关系评估为“可能相关”。使用艾沙康唑时应提高警惕，避免同时联用相同机制或有潜在相互作用的药物。如疗程大于2周或用药前血液系统异常或合并肝肾功能损害或需要联合使用相同机制的药物者，可考虑增加血常规监测频率。 |
| ABSTRACT： | OBJECTIVE To correctly identify and deal with the adverse drug reaction as pancytopenia caused by isavuconazonium and to provide reference for the safe use of isavuconazonium. METHODS Clinical pharmacists analyzed a case of severe infection and renal insufficiency who experienced pancytopenia after using isavuconazonium. Clinical pharmacists screened the drugs used during hospitalization and evaluated the relationship between this adverse drug reaction and isavuconazonium， as well as the possible mechanisms， based on the half-life of the drugs and relevant literature. RESULTS & CONCLUSIONS The relationship between pancytopenia and isavuconazonium was assessed as “possibly related”. When using isavuconazonium， attention should be paid to avoiding the combination of drugs with the same mechanism or potential interaction. For patients who have a course of treatment for more than 2 weeks， have hematological abnormalities or complicated with liver and renal insufficiency， or should use it combined with other drug with same mechanism， it may be considered to increase the frequency of blood routine monitoring. |
| 期刊： | 2024年第35卷第07期 |
| 作者： | 刘晓平；林小鲁；李剑芳 |
| AUTHORS： | LIU Xiaoping，LIN Xiaolu，LI Jianfang |
| 关键字： | 艾沙康唑；全血细胞减少；病例分析；药物不良反应 |
| KEYWORDS： | isavuconazonium； pancytopenia； case analysis； adverse drug reaction |
| 阅读数： | 14 次 |
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