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中药通过调节Th17/Treg平衡干预胃癌的研究进展
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| 篇名： | 中药通过调节Th17/Treg平衡干预胃癌的研究进展 |
| TITLE： | Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance |
| 摘要： | 胃癌（GC）是一种较为常见的消化道恶性肿瘤。辅助性T细胞17（Th17）和调节性T细胞（Treg）是CD4+T细胞的分化亚群，Th17/Treg的失衡已被证实与GC的发病进程密切相关。中药不仅可改善GC患者的生存预后，而且在GC的术后化疗中起到了增效减毒的效果。本文系统整理了中药通过调节Th17/Treg平衡干预GC的作用规律。结果发现，中药复方可通过发挥健脾益气、健脾温阳、化瘀解毒等功效以调节GC的Th17/Treg平衡；中药及其有效成分通过调节Th17/Treg平衡来干预GC的作用机制主要表现为抑制Th17、Treg的过度分化及其转录因子、细胞因子的过度表达，逆转GCTh17/Treg平衡向Th17或Treg的过度漂移，从而恢复GCTh17/Treg的免疫平衡。 |
| ABSTRACT： | Gastric cancer （GC） is a common malignant tumor of the digestive tract. T helper cells 17 （Th17） and T regulatory cells （Treg） are differentiated subsets of CD4+T cells. Th17/Treg imbalance has been shown to be closely related to the progression of GC. Traditional Chinese medicine （TCM） can not only improve the survival prognosis of GC patients， but also play a role in enhancing the efficacy and reducing the toxicity of postoperative chemotherapy for GC. This paper systematically sorted out the action rules of TCM in the intervention of GC by regulating Th17/Treg balance. The results showed that the TCM compound could regulate the balance of GC Th17/Treg by invigorating the spleen and invigorating Qi， warming Yang， removing blood stasis and detoxifying. The mechanism of regulating Th17/Treg balance in the intervention of GC is mainly to inhibit the excessive differentiation of Th17 and Treg and the overexpression of transcription factors and cytokines， reverse the excessive drift of GC Th17/Treg balance to Th17 or Treg， and thus restore the immune balance of GC Th17/Treg. |
| 期刊： | 2024年第35卷第03期 |
| 作者： | 尹嘉琪；黎丽群；谢胜 |
| AUTHORS： | YIN Jiaqi，LI Liqun，XIE Sheng |
| 关键字： | 中药；胃癌；辅助性T细胞17；调节性T细胞；免疫平衡；临床疗效；作用机制 |
| KEYWORDS： | traditional Chinese medicine； gastric cancer； T helper cell 17； T regulatory cells； immune balance； clinical effect； |
| 阅读数： | 101 次 |
| 本月下载数： | 2 次 |
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