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中药单体及复方干预mTOR信号通路治疗骨质疏松症的研究进展
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| 篇名： | 中药单体及复方干预mTOR信号通路治疗骨质疏松症的研究进展 |
| TITLE： | Research progress on the intervention of traditional Chinese medicine monomer and formula in the mTOR signaling pathway for the treatment of osteoporosis |
| 摘要： | 骨质疏松症是导致骨骼弱化、易于骨折的重要原因，西医抗骨质疏松药物并不能逆转其进程，只能减少骨密度的流失，且长期应用伴随一定不良反应，而中医药注重辨证施治和整体观念，可弥补西医治疗的短板。哺乳动物雷帕霉素靶蛋白（mTOR）信号通路参与骨细胞的生长、增殖和分化过程，与骨质疏松症的发生和发展密切相关。近年来，多种中药单体（如黄酮类、多糖类、生物碱类等）及中药复方（如补肾活血汤、六味地黄丸、二至丸等）被证明能够通过调节mTOR信号通路促进骨形成、抑制骨吸收、增强骨细胞自噬，进而延缓骨质疏松症的进展。基于此，本文总结了干预mTOR信号通路治疗骨质疏松症的中药单体及复方，以期为骨质疏松症的中医治疗提供用药思路。 |
| ABSTRACT： | Osteoporosis is an important cause of bone weakness and susceptibility to fractures. Anti-osteoporosis drugs of Western medicine cannot reverse its progression， and can only reduce the loss of bone density； long-term use of them is accompanied by certain adverse reactions. Traditional Chinese medicine focuses on syndrome differentiation and holistic approach， which can make up for the shortcomings of Western medicine’s treatment. The mammalian target of rapamycin （mTOR） signaling pathway is involved in the growth， proliferation， and differentiation of bone cells， and is closely related to the occurrence and development of osteoporosis. In recent years， various traditional Chinese medicine monomers （such as flavonoids， polysaccharides， alkaloids， etc.） and traditional Chinese medicine formulas （such as Bushen huoxue decoction， Liuwei dihuang pills， Erzhi pills， etc.） have been proven to promote bone formation， inhibit bone resorption， enhance bone cell autophagy， and delay the progression of osteoporosis by regulating the mTOR signaling pathway. Therefore， the article summarizes the traditional Chinese medicine monomer and formula that intervene in the mTOR signaling pathway for the treatment of osteoporosis， in order to provide medication ideas for the traditional Chinese medicine treatment of osteoporosis. |
| 期刊： | 2023年第34卷第23期 |
| 作者： | 陈言；单留峰；车文生；刘昱君；刘峙岐；史晓雪；冯志海 |
| AUTHORS： | CHEN Yan，SHAN Liufeng，CHE Wensheng，LIU Yujun，LIU Zhiqi，SHI Xiaoxue，FENG Zhihai |
| 关键字： | 中药；单体；复方；骨质疏松症；mTOR信号通路 |
| KEYWORDS： | traditional Chinese medicine； monomer； formula； osteoporosis； mTOR signaling pathway |
| 阅读数： | 59 次 |
| 本月下载数： | 2 次 |
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