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中药单体基于肠道菌群调节Th17/Treg轴对自身免疫性疾病的干预研究现状
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| 篇名： | 中药单体基于肠道菌群调节Th17/Treg轴对自身免疫性疾病的干预研究现状 |
| TITLE： | Intervention research status of traditional Chinese medicine monomers on autoimmune diseases by regulating Th17/Treg axis based on gut microbiota |
| 摘要： | 自身免疫性疾病（ADs）是一类机体对自身抗原发生免疫反应而导致自身组织损害的疾病。促炎性的辅助性T细胞17（Th17）和抗炎性的调节性T细胞（Treg）在功能上相互拮抗，两者间的免疫失衡及相关细胞因子失调与多种ADs发生密切相关。大量证据表明，肠道菌群可通过调节细胞因子产生、调控转录因子表达、影响能量代谢等调节Th17/Treg分化，重建自身免疫耐受，延缓ADs进程。本文综述了红景天苷、人参皂苷Rg1、白芍总苷、熊果酸等中药单体基于肠道菌群调节Th17/Treg分化平衡途径在干预溃疡性结肠炎、类风湿性关节炎、1型糖尿病等ADs中的作用，结果显示其作用机制可能为恢复促炎因子与抗炎因子平衡从而缓解肠黏膜屏障受损、降低滑膜血管新生及改善胰腺β细胞破坏等。这可为ADs的中西医结合防治提供思路。 |
| ABSTRACT： | Autoimmune diseases（ADs） are diseases in which the body’s immune tolerance is impaired， causing damage to its tissues. The pro-inflammatory helper T cell 17 （Th17） and anti-inflammatory regulatory T cell （Treg） are functionally antagonistic to each other， and the immune imbalance between them and the imbalance of related inflammatory factors are closely related to the occurrence of a variety of ADs. Plenty of evidence has shown that gut microbiota can regulate Th17/Treg differentiation， rebuild immune tolerance and delay the ADs process through regulating cytokine production， transcription factor expression and energy metabolism. This paper reviews the intervention effects of traditional Chinese medicine（TCM） monomers on the common ADs by regulating Th17/Treg differentiation balance based on intestinal flora： ulcerative colitis，rheumatoid arthritis and diabetes mellitus type 1. It is found that its mechanism of action may be to restore the balance of pro-inflammatory factors and anti-inflammatory factors to alleviate intestinal mucosal barrier damage， reduce synovial angiogenesis and improve pancreatic β cell destruction， which provides some ideas for the prevention and treatment of ADs with integrated traditional Chinese and western medicine. |
| 期刊： | 2023年第34卷第20期 |
| 作者： | 黄金雨；董政委；王永霞 |
| AUTHORS： | HUANG Jinyu，DONG Zhengwei，WANG Yongxia |
| 关键字： | 中药单体；自身免疫性疾病；肠道菌群；辅助性T细胞17；调节性T细胞 |
| KEYWORDS： | monomers of traditional Chinese medicine； autoimmune diseases； gut microbiota； helper T cell 17； regulatory |
| 阅读数： | 121 次 |
| 本月下载数： | 3 次 |
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