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麻杏咳喘颗粒的水提工艺优化
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| 篇名： | 麻杏咳喘颗粒的水提工艺优化 |
| TITLE： | Optimization of water extraction process of Maxing kechuan granules |
| 摘要： | 目的 优选麻杏咳喘颗粒的水提工艺。方法以药效成分盐酸麻黄碱、岩白菜素、升麻素苷、5-O-甲基维斯阿米醇苷、柚皮苷、橙皮苷含量及出膏率为考察指标，采用层次分析（AHP）-熵权法确定各指标权重，并计算综合评分作为响应值，在单因素实验的基础上采用Box-Behnken响应面法对各指标进行考察，优选麻杏咳喘颗粒的最佳水提工艺，并进行工艺验证。结果优选出麻杏咳喘颗粒的最佳水提工艺为浸泡时间40min，加水量8倍，总提取时间180min。经3次验证实验结果显示，综合评分为94.82分（RSD＝0.96%，n＝3），与预测值94.64分差异较小。结论优化后的麻杏咳喘颗粒水提工艺稳定可靠，可为该制剂的进一步开发提供参考。 |
| ABSTRACT： | OBJECTIVE To optimize the water extraction process of Maxing kechuan granules. METHODS With the contents of ephedrine hydrochloride， bergenin， prim-O-glucosylcimifugin， 5-O-methylvisamin， naringin and hesperidin and the rate of extraction as the evaluation indexes， the weight was determined by the analytic hierarchy process（APH）-entropy weight method， and the comprehensive score was calculated as the response value. Based on the single-factor test， the Box-Behnken response surface method was used to investigate the factors， and the best water extraction process of Maxing kechuan granules was optimized； process validation was also carried out. RESULTS The best water extraction process of Maxing kechuan granules optimized was as follows： soaking for 40 minutes， adding 8 times water， and extracting for 180 minutes. After three validation tests， the comprehensive score was 94.82 （RSD＝0.96%， n＝3）， which had a small difference from the predicted value of 94.64. CONCLUSIONS The water extraction process of Maxing kechuan granules is stable and reliable， which can provide a reference for the development of the preparation. |
| 期刊： | 2023年第34卷第17期 |
| 作者： | 梁董茜；王晶晶；王欣；柴天川；李春花 |
| AUTHORS： | LIANG Dongqian，WANG Jingjing，WANG Xin，CHAI Tianchuan，LI Chunhua |
| 关键字： | 麻杏咳喘颗粒；水提工艺；Box-Behnken响应面法；层次分析；熵权法；权重；综合评分 |
| KEYWORDS： | Maxing kechuan granules； water extraction process； Box-Behnken response surface method； analytic hierarchy |
| 阅读数： | 42 次 |
| 本月下载数： | 4 次 |
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