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桑根酮C药理作用及其机制的研究进展
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| 篇名： | 桑根酮C药理作用及其机制的研究进展 |
| TITLE： | Research progress on the pharmacological effects and mechanisms of sanggenon C |
| 摘要： | 桑根酮C是一种从中药桑白皮中提取分离出来的黄酮类化合物。本文就桑根酮C的药理作用及其作用机制进行系统梳理和归纳，发现该成分可通过调控转化生长因子β1、核因子κB来改善肺纤维化；可通过抑制肿瘤细胞增殖、诱导其凋亡来发挥抗肿瘤作用；可通过调控钙调磷酸酶/活化T细胞核因子2、过氧化物酶体增殖物激活受体α、Ras同源基因家族成员A/Rho相关卷曲螺旋蛋白激酶等多条信号通路，增强自噬，减轻炎症反应和降低氧化应激水平来发挥心脏保护、肝保护和神经保护作用；可通过抑制破骨细胞吸收并促进成骨细胞形成来发挥抗骨质疏松作用；对多种酶均有一定的抑制作用；可通过调控核因子κB信号通路来发挥抗炎作用；可通过清除自由基来发挥抗氧化作用。但有关桑根酮C的药理作用研究多集中在细胞和动物水平上，且具体作用机制尚不明确，今后仍需要开展基础研究和临床试验进行探索和验证。 |
| ABSTRACT： | Sanggenon C is a kind of flavonoid compound mainly extracted from the traditional Chinese medicine Morus alba. The pharmacological effects and mechanisms of sanggenon C are systematically reviewed and summarized， and it is found that this component can improve pulmonary fibrosis by regulating transforming growth factor-β1 and nuclear factor-κB； it can exert anti- tumor effects by inhibiting the proliferation of tumor cells and inducing the apoptosis of tumor cells； it can exert cardioprotective， neuroprotective and hepatoprotective effects by regulating multiple signaling pathways， such as calcineurin/nuclear factor of activated T cells 2， peroxisome proliferators-activated receptor α， and Ras homolog gene family member A/Rho-associated coiled- coil containing protein kinase， enhancing autophagy， reducing inflammatory response and reducing the level of oxidative stress； it can treat osteoporosis by inhibiting osteoclast uptake and promoting osteoblast formation； it has certain inhibitory effect on many enzymes； it can exert anti-inflammatory effects by regulating nuclear factor-κB signaling pathway； it can exert antioxidant effects by scavenging free radicals. However， researches on the pharmacological effects of sanggenon C mostly focus on the cellular and animal field， and the specific mechanism of action is not yet clear. In the future， basic research and clinical trials are still needed to explore and verify. |
| 期刊： | 2023年第34卷第16期 |
| 作者： | 刘剑波；毕小玲；王世华；张磊 |
| AUTHORS： | LIU Jianbo，BI Xiaoling，WANG Shihua，ZHANG Lei |
| 关键字： | 桑根酮C；药理作用；肺保护作用；抗肿瘤作用；心脏保护作用 |
| KEYWORDS： | sanggenon C； pharmacological effect； hepatoprotective effect； anti-tumor effect； cardioprotective effect |
| 阅读数： | 82 次 |
| 本月下载数： | 4 次 |
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