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中药活性成分调控mTOR信号通路干预糖尿病肾病的研究进展
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| 篇名： | 中药活性成分调控mTOR信号通路干预糖尿病肾病的研究进展 |
| TITLE： | Research progress of active ingredients of traditional Chinese medicine in the intervention of diabetic nephropathy by regulating mTOR signaling pathway |
| 摘要： | 糖尿病肾病（DN）是引起终末期肾病的主要病因之一，发病机制尚不完全清楚，目前认为与高糖条件下自噬紊乱、氧化应激、炎症反应等多种因素介导的肾脏损伤关系密切。哺乳动物雷帕霉素靶蛋白（mTOR）信号通路是参与蛋白质合成及调节自噬过程的核心通路，在DN的发生发展中起着重要作用。近年来，中医药防治DN的研究取得了关键性进展。大量证据表明，中药活性成分可通过调节mTOR信号通路提高自噬水平，改善氧化应激和炎症反应，抑制细胞的凋亡及异常增殖，从而缓解足细胞损伤、肾小球基底膜增厚、系膜组织异常及肾小管功能障碍等肾脏病理改变，减少蛋白尿并改善肾功能，对延缓DN进展具有重要意义。本文系统总结了中药皂苷类、黄酮类、多酚类、生物碱类、萜类等活性成分通过mTOR信号通路干预DN的研究进展，可为进一步的基础研究和临床新药开发提供一定参考。 |
| ABSTRACT： | Diabetic nephropathy （DN） has become one of the main causes of end-stage renal disease，and its pathogenesis is still unclear. Currently，it is believed to be closely related to kidney injury mediated by various factors such as autophagy disorder under the condition of high glucose，oxidative stress and inflammation. Mammalian target of rapamycin （mTOR） signaling pathway is crucial for protein synthesis and autophagy regulation，which plays an important role in the occurrence and development of DN. In recent years，the research on the prevention and treatment of DN with traditional Chinese medicine （TCM） has made important progress. Plenty of evidence has shown that the active ingredients of TCM can enhance autophagy，improve oxidative stress and inflammation，inhibit cell apoptosis and abnormal proliferation by regulating mTOR signaling pathway，so as to relieve pathological changes in the kidney such as podocyte injury，glomerular basement membrane thickening，mesangial tissue abnormalities and renal tubule dysfunction，thereby reducing proteinuria and improving renal function. All of the above are of great significance for delaying the progression of DN. This article systematically summarizes the research progress of saponins，flavonoids，polyphenols，alkaloids， terpenoids and other active ingredients of TCM intervening in DN through mTOR signaling pathway，in order to provide some reference for further basic research and the development of new drugs. |
| 期刊： | 2023年第34卷第13期 |
| 作者： | 贾慧雨；冯志海 |
| AUTHORS： | JIA Huiyu，FENG Zhihai |
| 关键字： | 糖尿病肾病；中药活性成分；哺乳动物雷帕霉素靶蛋白；信号通路 |
| KEYWORDS： | diabetic nephropathy； active ingredients of traditional Chinese medicine； mammalian target of rapamycin； |
| 阅读数： | 101 次 |
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