Box-Behnken响应面实验优化鳖血冻干粉的制备工艺
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篇名: Box-Behnken响应面实验优化鳖血冻干粉的制备工艺
TITLE: Optimization of the preparation process of Soft-shelled turtle blood lyophilized powder using Box-Behnken response surface methodology
摘要: 目的 优化鳖血冻干粉的制备工艺,为提高鳖血的服用便捷性和质量稳定性提供参考。方法采用真空冷冻干燥技术制备鳖血冻干粉。以溶解度为考察指标,通过单因素实验和Box-Behnken响应面实验优化鳖血冻干粉的冷冻干燥工艺参数,并验证。结果鳖血冻干粉最优冷冻干燥工艺为预冻时间4h、干燥时间13h(0℃前)、解析干燥温度25℃。3批按最优工艺制备的鳖血冻干粉的平均溶解度为95.72%(RSD=0.68%,n=3),与理论溶解度(96.66%)的相对误差为-0.97%。结论本研究优化的冷冻干燥工艺稳定可行,所制样品的溶解度较高。
ABSTRACT: OBJECTIVE To optimize the preparation process of Soft-shelled turtle blood lyophilized powder (STBLP), and to provide a reference for improving the availability and quality stability of soft-shelled turtle blood (STB). METHODS STBLP was prepared with vacuum freeze-drying. Taking the solubility as the index, the preparation process parameters of STBLP were optimized by single factor experiment and Box-Behnken response surface method. RESULTS The optimal freeze-drying process for STBLP was obtained: pre-freezing time of 4 h, total drying time of 13 h (before at 0 ℃), and resolution drying temperature of 25 ℃. The average solubility of 3 batches of STBLP prepared according to the optimal process was 95.72% (RSD=0.68%, n=3), the relative error of which was -0.97% to the theoretical solubility (96.66%). CONCLUSIONS Optimized lyophilization process in this study are stable and feasible, the solubility of the prepared sample is high.
期刊: 2023年第34卷第13期
作者: 娄悦;苏雪蓉;毛春芹;赵晓莉;陆兔林;皮文霞
AUTHORS: LOU Yue,SU Xuerong,MAO Chunqin,ZHAO Xiaoli,LU Tulin,PI Wenxia
关键字: 鳖血;真空冷冻干燥;溶解度;工艺优化
KEYWORDS: soft-shelled turtle blood; vacuum freeze-drying; solubility; process optimization
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