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Box-Behnken响应面实验优化鳖血冻干粉的制备工艺
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| 篇名： | Box-Behnken响应面实验优化鳖血冻干粉的制备工艺 |
| TITLE： | Optimization of the preparation process of Soft-shelled turtle blood lyophilized powder using Box-Behnken response surface methodology |
| 摘要： | 目的 优化鳖血冻干粉的制备工艺，为提高鳖血的服用便捷性和质量稳定性提供参考。方法采用真空冷冻干燥技术制备鳖血冻干粉。以溶解度为考察指标，通过单因素实验和Box-Behnken响应面实验优化鳖血冻干粉的冷冻干燥工艺参数，并验证。结果鳖血冻干粉最优冷冻干燥工艺为预冻时间4h、干燥时间13h（0℃前）、解析干燥温度25℃。3批按最优工艺制备的鳖血冻干粉的平均溶解度为95.72%（RSD＝0.68%，n＝3），与理论溶解度（96.66%）的相对误差为－0.97%。结论本研究优化的冷冻干燥工艺稳定可行，所制样品的溶解度较高。 |
| ABSTRACT： | OBJECTIVE To optimize the preparation process of Soft-shelled turtle blood lyophilized powder （STBLP）， and to provide a reference for improving the availability and quality stability of soft-shelled turtle blood （STB）. METHODS STBLP was prepared with vacuum freeze-drying. Taking the solubility as the index， the preparation process parameters of STBLP were optimized by single factor experiment and Box-Behnken response surface method. RESULTS The optimal freeze-drying process for STBLP was obtained： pre-freezing time of 4 h， total drying time of 13 h （before at 0 ℃）， and resolution drying temperature of 25 ℃. The average solubility of 3 batches of STBLP prepared according to the optimal process was 95.72% （RSD＝0.68%， n＝3）， the relative error of which was －0.97% to the theoretical solubility （96.66%）. CONCLUSIONS Optimized lyophilization process in this study are stable and feasible， the solubility of the prepared sample is high. |
| 期刊： | 2023年第34卷第13期 |
| 作者： | 娄悦；苏雪蓉；毛春芹；赵晓莉；陆兔林；皮文霞 |
| AUTHORS： | LOU Yue，SU Xuerong，MAO Chunqin，ZHAO Xiaoli，LU Tulin，PI Wenxia |
| 关键字： | 鳖血；真空冷冻干燥；溶解度；工艺优化 |
| KEYWORDS： | soft-shelled turtle blood； vacuum freeze-drying； solubility； process optimization |
| 阅读数： | 125 次 |
| 本月下载数： | 1 次 |
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